Table Info

Table 3.

Clinically approved treatments for neurological disorders induced by mitochondrial dysfunction

Drug name	Activity	Clinical trial number
EPI-743	Antioxidant	NCT01721733
KH176	Antioxidant	NCT02544217
RP103 (cysteamine bitartrate delayed release)	Cystine-depleting agent	NCT02023866
Idebenone	Antioxidant	NCT00887562
RP103 (cysteamine bitartrate delayed release)	Cystine-depleting agent	NCT02473445
Medium chain triglycerides	Shift heteroplasmy	NCT01252979
L-arginine	NO precursor	NCT01603446
L-arginine (IV)	NO precursor	JMA-IIA00023
L-arginine (PO)	NO precursor	JMA-IIA00025
Arginine and citrulline	NO precursor	NCT01339494
Taurine	Taurine modification	UMIN000011908
Pyruvate	NAD donor	JMA-IIA00093
DCA	Lowering lactate levels	NCT00068913

DCA: dichloroacetate; NO: nitric oxide

Declarations

Author contributions

MY and AK contributed conception and design of the study; N Singh, MD and NR organized the paper; N Sharma performed the reference setting and formating; MY wrote the first draft of the manuscript; JD, N Sharma, PD and NM wrote sections of the manuscript. All authors contributed to manuscript revision, read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

The authors are thankful to Science and Engineering Research Board-Department of Science and Technology (SERB-DST, New Delhi, Letter number PDF/2018/002605) and GD Goenka University, Gurgaon, 122103, India [Seed Grant (R&D.12/21/01)] for the financial support to get the access to the journals which are paid and the data included in this paper are from these journals and provided funds to attend conferences and workshops to collect data for this paper.

Copyright

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