Comparisons between the abnormal and normal glucose tolerance groups
Variables | AGT (n = 150) | Normal glucose tolerance (n = 729) | P-value |
---|---|---|---|
Age (years) | 13.3 ± 2.6 | 12.1 ± 2.8 | < 0.001 |
Age group (%) | 0.001 | ||
6–11 years | 32.0 | 46.5 | |
12–18 years | 68.0 | 53.5 | |
Sex | < 0.001 | ||
Male | 13.7 | 86.3 | |
Female | 23.0 | 77.0 | |
AN | 68.7 | 53.4 | < 0.001 |
Body weight (kg) | 72.7 ± 16.6 | 66.6 ± 18.7 | < 0.001 |
Body height (cm) | 156.8 ± 10.6 | 152.5 ± 14.5 | < 0.001 |
BMI (kg/m2) | 29.2 ± 4.3 | 28.0 ± 3.9 | < 0.001 |
z-score | 2.3 ± 0.4 | 2.2 ± 0.4 | 0.790 |
Mean systolic BP (mmHg) | 119.1 ± 10.4 | 115.8 ± 9.6 | < 0.001 |
z-score | 0.9 ± 0.9 | 0.8 ± 0.9 | 0.460 |
Mean diastolic BP (mmHg) | 63.6 ± 7.5 | 61.2 ± 7.2 | < 0.001 |
z-score | –0.2 ± 0.8 | –0.3 ± 0.9 | 0.072 |
Fasting glucose (mmol/L) | 5.3 ± 0.7 | 4.9 ± 0.3 | < 0.001 |
Postprandial glucose (mmol/L) | 8.7 ± 1.7 | 6.0 ± 0.9 | < 0.001 |
Fasting insulin (μU/mL) | 26.1 ± 15.8 | 17.1 ± 11.4 | < 0.001 |
HOMA-IR | 6.3 ± 4.6 | 3.7 ± 2.6 | < 0.001 |
HOMA-IR ≥ 4.1 (%) | 65.7 | 32.5 | < 0.001 |
ALT (units/L) | 44.0 ± 56.5 | 32.3 ± 37.7 | 0.002 |
Total cholesterol (mmol/L) | 4.8 ± 0.9 | 4.6 ± 0.8 | 0.003 |
HDL (mmol/L) | 1.2 ± 0.3 | 1.3 ± 0.4 | 0.010 |
LDL (mmol/L) | 2.8 ± 0.8 | 2.6 ± 0.8 | 0.005 |
TG (mmol/L) | 1.6 ± 0.7 | 1.4 ± 0.7 | < 0.001 |
∞ Percentage of glucose tolerance status within sex group; @ AN status was available for analysis in 869 children; a chi-square test, expressed in median (IQR); b student’s t-test, expressed in mean ± SD; * statistically significant with P < 0.05. IQR: interquartile range
VYHL, JHMY, HYN, and LTWC: Conceptualization, Investigation, Writing—original draft, Writing—review & editing. All authors read and approved the submitted version.
The authors declare that they have no conflicts of interest.
This study was reviewed and approved by the Research Ethics Committee (Kowloon Central/Kowloon East) of Hospital Authority, Hong Kong Special Administrative Region (Reference No.: KC/KE-19-0043/ER-4).
The need for patient consent was waived by the Research Ethics Committee (Kowloon Central/Kowloon East) of Hospital Authority for this retrospective cohort study because no personal identifiers or related information were obtained during the data collection process.
The need for patient consent was waived by the Research Ethics Committee (Kowloon Central/Kowloon East) of Hospital Authority for this retrospective cohort study because no personal identifiers or related information were obtained during the data collection process.
All relevant data are contained within the manuscript.
Not applicable.
© The Author(s) 2023.