Baseline biochemical characteristics of study participants based on inflammatory status
Variables
Overall mean ± SDn = 360 (108.2 ± 44.6)
Inflammatory status
P value
No (QB)NLR (≤ 3.53)n = 259 (71.9%)
Yes (QA)NLR (> 3.53)n = 101 (28.1%)
Age (years)
53.7 ± 13.9
53.4 ± 14.2
54.4 ± 13.2
0.549
Biochemical parameters
Sodium (mg/dL)
139.6 ± 5.5
140.0 ± 5.5
138.5 ± 5.4
0.020
Potassium (mEq/L)
4.79 ± 0.7
4.76 ± 0.6
4.88 ± 0.8
0.162
Urea (mg/dL)
77.8 ± 42.0
73.4 ± 36.3
89.2 ± 52.4
0.001
Creatinine (mg/dL)
2.43 ± 2.7
2.23 ± 0.7
2.93 ± 5.0
0.029
Calcium (mg/dL)
9.20 ± 1.16
9.29 ± 1.17
8.97 ± 1.14
0.021
Phosphorus (mg/dL)
4.44 ± 1.40
4.32 ± 1.18
4.75 ± 1.82
0.008
Uric acid (mg/dL)
7.49 ± 2.10
7.49 ± 2.07
7.48 ± 2.19
0.973
ALP (mg/dL)
108.2 ± 44.6
105.3 ± 37.3
115.6 ± 59.0
0.049
eGFR (mL per min/1.73 m2)
33.8 ± 15.3
33.9 ± 16.1
30.2 ± 12.9
0.040
S albumin (g/dL)
3.99 ± 0.75
3.75 ± 0.77
4.06 ± 0.73
≤ 0.005
Hb1Ac (%)
6.93 ± 1.85
6.93 ± 1.81
6.95 ± 1.96
0.912
Hemoglobin (g/L)
10.73 ± 2.31
10.92 ± 2.22
10.23 ± 2.48
0.011
TC (g/L)
179.9 ± 56.6
180.4 ± 52.5
178.7 ± 66.1
0.800
TG (g/L)
159.1 ± 72.9
163.9 ± 78.3
146.8 ± 55.0
0.046
HDL-c (g/L)
45.8 ± 15.3
45.0 ± 13.2
48.1 ± 19.6
0.080
LDL-c (g/L)
100.9 ± 43.2
101.2 ± 40.3
100.2 ± 50.0
0.848
VLDL (g/L)
34.8 ± 28.2
36.6 ± 32.3
29.9 ± 11.5
0.043
Anthropometry
BMI (kg/m2)
24.0 ± 4.3
24.2 ± 4.31
23.6 ± 4.35
0.281
SBP (mmHg)
149.3 ± 24.8
147.6 ± 25.0
153.6 ± 23.8
0.038
DBP (mmHg)
88.3 ± 14.0
88.1 ± 14.5
88.8 ± 12.6
0.706
SGA score
10.4 ± 6.5
9.7 ± 6.4
12.3 ± 6.5
0.001
Data presented as mean with SD. eGFR in all patients were estimated by the CKD-EPI formula. P value < 0.05 taken as significant. DBP: diastolic blood pressure; HDL-c: high-density lipoprotein cholesterol; LDL-c: low-density lipoprotein cholesterol; S albumin: serum albumin; SBP: systolic blood pressure; SGA: subjective global assessment; TC: total cholesterol; TG: triglyceride; VLDL: very low-density lipoprotein
The authors extend their gratitude towards all the participants and those who carried out the extensive clinical and laboratory work at the clinical site.
Author contributions
IR: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing—original draft. PT: Conceptualization, Methodology, Supervision, Validation, Writing—original draft. SDC and SJ: Conceptualization, Methodology, Supervision, Validation. All authors contributed to manuscript revision, read and approved the submitted version.
Conflicts of interest
The authors declare that they have no conflicts of interest.
Ethical approval
This study is approved by the Institutional Ethics Committee GMCH & NIPER and Research Committee GMCH and complies with the Declaration of Helsinki.
Consent to participate
Informed consent to participate in the study was obtained from all participants.
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