Exploration of Medicine

From: Lactate metabolic pathway regulates tumor cell metastasis and its use as a new therapeutic target

Table 2. List of information on MCTs inhibitors

MCTs inhibitors	Site of action	Shortcomings	References
Lonidamine	MCT1, MCT2, MCT4	Less effective	[102]
Quercetin	MCT1	Does not affect cell migration	[103, 106]
Simvastatin	MCT4	Does not affect cell migration	[104, 106]
DIDS	MCT Family	Does not affect cell migration	[105, 106]
AR-C155858	MCT1 (K_i = 2.3 nM), MCT2	Novel inhibitors to be studied	[107]
AZD3965	MCT1 (K_i = 1.6 nM), MCT2 (K_i = 20 nM)	Novel inhibitor in Phase I clinical trials	[16, 111, 113]
BAY-8002	MCT1, MCT2 (MCT1 is 5 times more selective than MCT2)	Novel inhibitor, not in clinical trials	[114]
Bindarit	MCT4	Newly identified inhibitors to be studied	[115]
VB124	MCT4	Novel inhibitors to be studied	[117]

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DIDS: 4,4’-diisothiocyanatostilbene-2,2’-disulfonic acid

Declarations

Author contributions

WX, XL, and YZ: Writing—original draft. MZ and ML: Writing—review & editing, Supervision.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

This work is supported by the National Natural Science Foundation of China [81960519, 81660463, 82060514], the Natural Science Foundation of Hainan Province [2019CXTD406], and Hainan Province Science and Technology Special Fund [ZDYF2021SHFZ222]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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