Table Info

Table 1.

Examples of preclinical studies and clinical trials on vaccines developed for infectious diseases

Disease	Vector	Findings
CHIKV	MV-CHIKV	Protection against CHIKV challenges in macaques [63]
	MV-CHIKV	Seroconversion in 100% of volunteers in phase I [64]
	MV-CHIKV	Good safety, and strong immune responses in phase II [65]
EVD	VSV-EBOV-GP	Protection against two EBOV strains in macaques [66, 67]
	VSV-EBOV-GP	Good safety and tolerability in phase I volunteers [68]
	VSV-ZEBOV	High vaccine efficacy, and protection in phase III [69]
	VSV-ZEBOV	High vaccine efficacy in phase III volunteers [70]
	VSV-ZEBOV	Approval of ERVEBO® by the FDA and EMA [71]
ZIKV	MV-ZIKV-E	ZIKV-specific Abs, protection against ZIKV of mice fetus [72]
	MV-ZIKV-E	Despite the completion of phase I, no results are available [73]
	MV-ZIKV-RSP-E	Phase I study in progress [75]
	MV (TMV-083)	Th1-biased Ab and T cell responses in mice [76]
	MV (TMV-083)	Weak immune responses, phase I trial discontinued [77, 78]
COVID-19	VSV-SARS-CoV-2 S	Protection against SARS-CoV-2 challenges in mice [79]
	VSV (V590)	Weak immune responses, phase I trial discontinued [80, 81]
	VSVΔG-SARS-CoV-2 S	Protection against SARS-CoV-2 in hamsters [82]
	VSVΔG-SARS-CoV-2 S	Phase I/II study in progress [83]
	LNP-nCoVsaRNA	Strong SARS-CoV-2 specific Ab responses in mice [86]
	LNP-nCoVsaRNA	Safe but not 100% seroconversion in phase I [87]

Ab: antibody; CHIKV: chikungunya virus; EBOV-GP: Ebola virus-glycoprotein; EMA: European Medicines Agency; EVD: Ebola virus disease; FDA: US Food and Drug Administration; LNP: lipid nanoparticle; LNP-nCoVsaRNA: LNP-VEE-SARS-CoV-2 S RNA; SARS-CoV-2 S: SARS-CoV-2 spike; ZEBOV: EBOV-Zaire strain

Declarations

Author contributions

KL is the sole author of the manuscript and contributed to: Conceptualization, Writing—original draft, Writing—review & editing.

Conflicts of interest

The author declares that he has no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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