GEM 100 mg/kg per day i.p.; every 3 days, or a combination of CBD + GEM
Mice receiving CBD + GEM survived 2.8 times longer than mice not given any treatment (1.3 times longer with CBD and 1.4 times longer with GEM alone); mean survival: no treatment 18.6, CBD 25.4 (+ 37%), GEM 27.8 (+ 49%), CBD + GEM 52.7 days (+ 183%)
Human PDAC cell line (Capan-2)-derived xenograft mouse model
Extract (CBD:THC = 6:1) 1 mg/kg, 5 mg/kg, or extract 10 mg/kg p.o. per day
5-FU, 5 mg/kg i.p., three times a week, compared to a negative control group (sesame oil)
Tumour volumes were marginally but not significantly lower than after 5-FU in the 1 mg and 5 mg/kg extract group, whereas the volume of the 10 mg/kg group was higher than that of the negative control (not signif.)
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