Detailed examination of the relationship between CD34+CD133+ (log-transformed) and the risk of AD/dementia risk

CD34+CD133+ cells plus covariatesADAll-cause dementia
HR (95% CI)P valueHR (95% CI)P value
Model 1: no covariates0.57 (0.40, 0.81)
n = 1,617		0.002*0.57 (0.42, 0.77)
n = 1,640		0.003*
Model 2: age, sex, years of education0.64 (0.45, 0.93)
n = 1,617		0.02*0.64 (0.47, 0.87)
n = 1,640		0.005*
Model 3: Model 2 + APOE ɛ4 + vascular diseases0.64 (0.44, 0.94)
n = 1,340		0.02*0.63 (0.45, 0.87)
n = 1,362		0.006*
Model 3 after stratification
        No vascular diseasesa1.23 (0.15, 10.18)
n = 256		0.851.12 (0.19, 6.56)
n = 257		0.90
        Peripheral vascular diseasesb only0.62 (0.40, 0.94)
n = 832		0.02*0.61 (0.43, 0.88)
n = 850		0.008*
        Cerebrovascular diseasesc only0.58 (0.35, 0.96)
n = 628		0.03*0.53 (0.35, 0.81)
n = 641		0.003*

Cox proportional hazards regression models were used to study the relationship between log-transformed CD34+CD133+ cell frequency (%) and the risk of AD or all-cause dementia after adjusting for the covariates. HR with 95% CI with P values is shown. Model 1: simple association without confounders; Model 2: adjusting for age, sex, and education; Model 3: Model 2 + APOE ɛ4 + vascular diseases. a Model 3 after the stratification as no vascular diseases for those with no CHD, no HTN, no stroke, no silent infarct, no CMB, and low level of WMHI; b Model 3 after the stratification as peripheral vascular diseases for those with CHD or HTN; c Model 3 after the stratification as cerebrovascular diseases for those with stroke, silent infarct, CMB, or high level of WMHI; * P value significant < 0.05