Interactions between SNPs of KIRREL3 or EXOC6B and CD34+CD133+ on AD risk in FHS

Gene locusChr:Pos (GRCh37)Major alleleMinor alleledbSNP IDFunctionMAFAD risk
Main effect of SNPaInteraction effect (GEEPACK)
(SNP with CD34+CD133+)b		Interaction effect (Cox)
(SNP with CD34+CD133+)c
OR
(95% CI)		P valueOR
(95% CI)		P valueHR
(95% CI)		P value
KIRREL3chr11:126434673TGrs4144611Intron0.391.12 (–0.15, 0.37)0.405.52 (3.18, 9.56)1.3 × 10–8*2.71 (1.67, 4.40)5.61 × 10–7*
KIRREL3chr11:126438111CTrs580382Intron0.351.07 (–0.20, 0.33)0.625.00 (2.98, 8.39)1.3 × 10–8*3.69 (2.21, 6.14)5.28 × 10–5*
EXOC6Bchr2:72754104CGrs61619102Intron0.160.96 (–0.39, 0.31)0.844.66 (2.79, 7.80)4.2 × 10–8*4.69 (2.05, 10.75)2.59 × 10–4*

a Using logistic regression model, AD was associated with different SNPs after adjusting for age, sex, years of education, APOE ɛ4, and PCs; b using GWAS GEEPACK (logistic regression utilizing generalized estimating equations), AD was associated with different SNPs, (CD34+CD133+) and SNP:(CD34+CD133+) after adjusting for age, sex, years of education and PCs; c Using Cox proportional hazards regression model, AD incidence was associated with SNP, (CD34+CD133+), the interaction between SNP and (CD34+CD133+) after adjusting for age, sex, years of education, APOE ɛ4, PCs, and vascular diseases; * P value significant < 0.05; Chr: chromosome; Pos: position