aMMP-8 PISF mean values and clinical parameters of implant sites for the different groups, before and after treatment

VariableTime-pointHealthy (H)Peri-implant mucositis (PIM)Peri-implantitis (P)Multiple comparisons
aMMP-8
(ng/mL)		T0
T3		11.44 ± 6.60
9.83 ± 3.10		13.69 ± 4.70
11.98 ± 4.90		24.60 ± 3.20
20.85 ± 5.40		H vs. PIM
H vs. P*
PIM vs. P*
sGIT0
T3		0.54 ± 0.05
0.42 ± 0.05		2.18 ± 0.27
1.53 ± 0.35
(T0 vs. T3*)		2.82 ± 0.50
2.11 ± 0.62		H vs. PIM*
H vs. P*
PIM vs. P*
mPIT0
T3		1.20 ± 0.05
0.32 ± 0.23
(T0 vs. T3*)		1.88 ± 0.61
1.33 ± 0.76
(T0 vs. T3*)		2.29 ± 0.54
1.93 ± 0.21
(T0 vs. T3*)		H vs. PIM*
H vs. P*
PIM vs. P
mBOPIT0
T3		0.11 ± 0.32
0.08 ± 0.09		1.74 ± 0.40
1.17 ± 0.28
(T0 vs. T3*)		2.22 ± 0.27
1.53 ± 0.68		H vs. PIM*
H vs. P*
PIM vs. P
PD (mm)T0
T3		1.93 ± 0.27
1.88 ± 0.35		2.70 ± 0.46
2.47 ± 0.78		5.06 ± 1.12
4.78 ± 0.74		H vs. PIM
H vs. P*
PIM vs. P*
rMBL (mm)T0
T3		2.20 ± 0.40
2.10 ± 0.70		3.30 ± 0.50
3.10 ± 0.40		6.40 ± 1.20
6.10 ± 0.90		H vs. PIM
H vs. P*
PIM vs. P*

Values are presented as mean ± SD. *: P ≤ 0.05