Clinical studies data on various mushrooms showing anticancer potential
S. No.
Mushroom
Cancer
Phase
Bioactive components
Result
1
Agaricus bisporus
Breast cancer
Phase I completed
Polysaccharides, lectin
Reduced cancer by bringing down immunosuppressive factors.
Prostate cancer
Phase Ib completed, n = 32
Polysaccharides, lectin
2
Agaricus blazei
Multiple myeloma
Phase II completed, randomized clinical trial, n = 100
Genistein
Patients with cervical, ovarian, or endometrial cancer who were having chemotherapy did not vary significantly from those who were not treated with regard to lymphokine-activated killer or monocyte activity. Furthermore, verum only showed improvement in a number of negative effects when combined with mushroom extract.
3
Lentinula edodes
Prostate cancer
Phase II completed, n = 74
CombinedPolysaccharide(GCP)
In individuals with early-stage prostate cancer, mushroom extract did not lower prostate specific antigen by more than 50%.
Hepatocellular carcinoma and hepatitis B & C
Phase II completed
Arabinoxylan
--
4
Grifola frondosa
Breast and lung cancer
Phase I completed, n = 34
Polysaccharides
In peripheral blood samples taken from postmenopausal breast cancer patients, maitake extracts had an effect on immunological stimulatory and inhibitory characteristics.
5
Omphalotus illudens
Thyroid cancer, metastatic or recurrent gastric cancer, recurrent or persistent epithelial ovarian cancer
Phase II completed
Illudin S semisynthetic derivative
--
6
Trametes versicolor
Gastric cancer
Controlled trial, n = 60
Krestin, PSK, PSP
Chemotherapy alleviated Qi and Yin deficit symptoms in gastric cancer patients.
7
Agaricus sylvaticus
Breast cancer
Randomized clinical trial, n = 46
--
Enhanced nutritional status with decreased side effects in stage II & III breast cancer patients, including nausea, vomiting, and anorexia.
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