Number of animals (%) with histological lesions in the lungs, liver, spleen, and kidney in all experimental groups
| Histological organs lesions | G1 WT water | G2 HPV water | G3 WT 0.013 g/mL | G4 HPV 0.006 g/mL | G5 HPV 0.008 g/mL | G6 HPV 0.013 g/mL | |
|---|---|---|---|---|---|---|---|
| Lungs | |||||||
| Mononucleated inflammation intensity | 0(0%) | 3(60%) | 0(0%) | 1(20%) | 1(20%) | 1(20%) | |
| Atelectasis | 0(0%)1 | 5(100%) | 2(40%) | 1(20%) | 1(20%) | 4(80%) | |
| Congestion | 3(60%) | 5(100%) | 0(0%) | 2(40%) | 0(0%) | 3(60%) | |
| Hyperaemia | 4(80%) | 0(0%) | 0(0%) | 0(0%) | 0(0%) | 0(0%) | |
| Liver | |||||||
| Hydropic degeneration | 0(0%) | 1(20%) | 0(0%) | 0(0%) | 2(40%) | 0(0%) | |
| Inflammatory infiltrate | Periportal | 0(0%) | 0(0%) | 0(0%) | 0(0%) | 0(0%) | 0(0%) |
| Centrilobular | 0(0%) | 0(0%) | 0(0%) | 0(0%) | 0(0%) | 0(0%) | |
| Midzonal | 0(0%) | 5(100%) | 3(60%) | 3(60%) | 3(60%) | 1(20%) | |
| Congestion | 5(100%) | 5(100%) | 1(20%) | 2(40%) | 3(60%) | 5(100%) | |
| Spleen | |||||||
| Diffuse white pulp: hyperplasia | 0(0%) | 0(0%) | 2(40%) | 1(20%) | 4(80%) | 1(20%) | |
| Expansion of the splenic red pulp: congestion | 0(0%) | 4(80%) | 0(0%) | 0(0%) | 0(0%) | 0(0%) | |
| Kidney | |||||||
| Inflammatory infiltrate | 1(20%) | 5(100%) | 0(0%) | 3(60%) | 3(60%) | 3(60%) | |
| Hydronephrosis | 1(20%) | 4(80%) | 1(20%) | 1(20%) | 1(20%) | 0(0%) | |
| Congestion | 5(100%) | 5(100%) | 5(100%) | 3(60%) | 5(100%) | 5(100%) | |
| Hyperaemia | 1(20%) | 3(60%) | 0(0%) | 0(0%) | 1(20%) | 0(0%) | |
| Vascular ectasia | 0(0%) | 1(20%) | 0(0%) | 0(0%) | 0(0%) | 0(0%) | |
1 Significantly different from the G2 (P < 0.05). G1 are wild-type (WT) mice that drink water; G2 are mice with human papillomavirus (HPV) that drank water; G3 are WT that drank daily an aqueous extract of Aloysia citrodora at a concentration of 0.013 g/mL; G4 are mice with HPV that drank daily an aqueous extract of A. citrodora at a concentration of 0.006 g/mL; G5 are mice with HPV that drank daily an aqueous extract of A. citrodora at a concentration of 0.008 g/mL; G6 are mice with HPV that drank daily an aqueous extract of A. citrodora at a concentration of 0.013 g/mL
