Table Info

Table 1.

Natural polysaccharides and their components and charges

Polysaccharides	Major monosaccharides	Minor monosaccharides	Charge	Reference(s)
Carrageenan	Sulfated D-galactose		Sulfated, negatively charged	[58, 62]
Fucoidan	Fucose	Mannose, galactose, xylose, glucose, rhamnose, glucuronic acid, arabinose	Sulfated, negatively charged	[63, 64]
Chitosan	D-glucosamine	N-acetyl-D-glucosamine	Positively charged by amine groups	[65, 66]
Alginate	β-1,4-D-mannuronic acid (MnA) and α-1,4-L-guluronic acid (GlcA)		Negatively charged	[59, 67]
Guar gum	Galactose, mannose		No charge	[68]

Blank cells represent not applicable

Declarations

Author contributions

WD: Conceptualization, Writing—original draft. LDM and JL: Writing—review & editing.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

References

Vinderola G, Sanders ME, Salminen S, Szajewska H. Postbiotics: The concept and their use in healthy populations. Front Nutr. 2022;9:1002213. [DOI] [PubMed] [PMC]

Sun Z, Zhao Z, Fang B, Hung W, Gao H, Zhao W, et al. Effect of Thermal Inactivation on Antioxidant, Anti-Inflammatory Activities and Chemical Profile of Postbiotics. Foods. 2023;12:3579. [DOI] [PubMed] [PMC]

Ooi MF, Foo HL, Loh TC, Mohamad R, Rahim RA, Ariff A. A refined medium to enhance the antimicrobial activity of postbiotic produced by Lactiplantibacillus plantarum RS5. Sci Rep. 2021;11:7617. [DOI] [PubMed] [PMC]

Johnson CN, Kogut MH, Genovese K, He H, Kazemi S, Arsenault RJ. Administration of a Postbiotic Causes Immunomodulatory Responses in Broiler Gut and Reduces Disease Pathogenesis Following Challenge. Microorganisms. 2019;7:268. [DOI] [PubMed] [PMC]

Alan Y, Savcı A, Koçpınar EF, Ertaş M. Postbiotic metabolites, antioxidant and anticancer activities of probiotic Leuconostoc pseudomesenteroides strains in natural pickles. Arch Microbiol. 2022;204:571. [DOI] [PubMed]

Martorell P, Alvarez B, Llopis S, Navarro V, Ortiz P, Gonzalez N, et al. Heat-Treated Bifidobacterium longum CECT-7347: A Whole-Cell Postbiotic with Antioxidant, Anti-Inflammatory, and Gut-Barrier Protection Properties. Antioxidants (Basel). 2021;10:536. [DOI] [PubMed] [PMC]

Kullar R, Goldstein EJC, Johnson S, McFarland LV. Lactobacillus Bacteremia and Probiotics: A Review. Microorganisms. 2023;11:896. [DOI] [PubMed] [PMC]

Devi R, Sharma E, Thakur R, Lal P, Kumar A, Altaf MA, et al. Non-dairy prebiotics: Conceptual relevance with nutrigenomics and mechanistic understanding of the effects on human health. Food Res Int. 2023;170:112980. [DOI] [PubMed]

Cuevas-González PF, Liceaga AM, Aguilar-Toalá JE. Postbiotics and paraprobiotics: From concepts to applications. Food Res Int. 2020;136:109502. [DOI] [PubMed]

10.

Gurunathan S, Thangaraj P, Kim J. Postbiotics: Functional Food Materials and Therapeutic Agents for Cancer, Diabetes, and Inflammatory Diseases. Foods. 2023;13:89. [DOI] [PubMed] [PMC]

11.

Park M, Joung M, Park J, Ha SK, Park H. Role of Postbiotics in Diet-Induced Metabolic Disorders. Nutrients. 2022;14:3701. [DOI] [PubMed] [PMC]

12.

Feng Y, Wassie T, Gan R, Wu X. Structural characteristics and immunomodulatory effects of sulfated polysaccharides derived from marine algae. Crit Rev Food Sci Nutr. 2023;63:7180–96. [DOI] [PubMed]

13.

Yuan D, Li C, Huang Q, Fu X, Dong H. Current advances in the anti-inflammatory effects and mechanisms of natural polysaccharides. Crit Rev Food Sci Nutr. 2023;63:5890–910. [DOI] [PubMed]

14.

Huang G, Mei X, Hu J. The Antioxidant Activities of Natural Polysaccharides. Curr Drug Targets. 2017;18:1296–300. [DOI] [PubMed]

15.

Gan Q, Wang J, Hu J, Lou G, Xiong H, Peng C, et al. Modulation of Apoptosis by Plant Polysaccharides for Exerting Anti-Cancer Effects: A Review. Front Pharmacol. 2020;11:792. [DOI] [PubMed] [PMC]

16.

Zhang Y, Lu J, Li H, Song H. Advances in dietary polysaccharides as hypoglycemic agents: mechanisms, structural characteristics, and innovative applications. Crit Rev Food Sci Nutr. 2023;14:1–21. [DOI] [PubMed]

17.

Dong X, Zhou M, Li Y, Li Y, Ji H, Hu Q. Cardiovascular Protective Effects of Plant Polysaccharides: A Review. Front Pharmacol. 2021;12:783641. [DOI] [PubMed] [PMC]

18.

Huang Y, Chen H, Zhang K, Lu Y, Wu Q, Chen J, et al. Extraction, purification, structural characterization, and gut microbiota relationship of polysaccharides: A review. Int J Biol Macromol. 2022;213:967–86. [DOI] [PubMed]

19.

Wassie T, Lu Z, Duan X, Xie C, Gebeyew K, Yumei Z, et al. Dietary Enteromorpha Polysaccharide Enhances Intestinal Immune Response, Integrity, and Caecal Microbial Activity of Broiler Chickens. Front Nutr. 2021;8:783819. [DOI] [PubMed] [PMC]

20.

Guo R, Pang J, Zhao J, Xiao X, Li J, Li J, et al. Unveiling the neuroprotective potential of dietary polysaccharides: a systematic review. Front Nutr. 2023;10:1299117. [DOI] [PubMed] [PMC]

21.

Rang Y, Liu H, Liu C. Potential for non-starch polysaccharides in the prevention and remediation of cognitive impairment: A comprehensive review. Int J Biol Macromol. 2022;208:182–95. [DOI] [PubMed]

22.

Zhang D, Liu J, Cheng H, Wang H, Tan Y, Feng W, et al. Interactions between polysaccharides and gut microbiota: A metabolomic and microbial review. Food Res Int. 2022;160:111653. [DOI] [PubMed]

23.

Xiao M, Jia X, Wang N, Kang J, Hu X, Goff HD, et al. Therapeutic potential of non-starch polysaccharides on type 2 diabetes: from hypoglycemic mechanism to clinical trials. Crit Rev Food Sci Nutr. 2024;64:1177–210. [DOI] [PubMed]

24.

Sivanesan I, Muthu M, Gopal J, Oh J. Mushroom Polysaccharide-Assisted Anticarcinogenic Mycotherapy: Reviewing Its Clinical Trials. Molecules. 2022;27:4090. [DOI] [PubMed] [PMC]

25.

Zhang Y, Zhang M, Jiang Y, Li X, He Y, Zeng P, et al. Lentinan as an immunotherapeutic for treating lung cancer: a review of 12 years clinical studies in China. J Cancer Res Clin Oncol. 2018;144:2177–86. [DOI] [PubMed]

26.

Sakamoto J, Morita S, Oba K, Matsui T, Kobayashi M, Nakazato H, et al.; Meta-Analysis Group of the Japanese Society for Cancer of the Colon Rectum. Efficacy of adjuvant immunochemotherapy with polysaccharide K for patients with curatively resected colorectal cancer: a meta-analysis of centrally randomized controlled clinical trials. Cancer Immunol Immunother. 2006;55:404–11. [DOI] [PubMed] [PMC]

27.

Kantak MN, Bharate SS. Analysis of clinical trials on biomaterial and therapeutic applications of chitosan: A review. Carbohydr Polym. 2022;278:118999. [DOI] [PubMed]

28.

De Man JC, Rogosa M, Sharpe ME. A medium for the cultivation of lactobacilli. J Appl Bacteriol. 1960;23:130–5. [DOI]

29.

Salminen S, Collado MC, Endo A, Hill C, Lebeer S, Quigley EMM, et al. The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics. Nat Rev Gastroenterol Hepatol. 2021;18:649–67. [DOI] [PubMed] [PMC]

30.

Thorakkattu P, Khanashyam AC, Shah K, Babu KS, Mundanat AS, Deliephan A, et al. Postbiotics: Current Trends in Food and Pharmaceutical Industry. Foods. 2022;11:3094. [DOI] [PubMed] [PMC]

31.

Mosca A, Abreu Y Abreu AT, Gwee KA, Ianiro G, Tack J, Nguyen TVH, et al. The clinical evidence for postbiotics as microbial therapeutics. Gut Microbes. 2022;14:2117508. [DOI] [PubMed] [PMC]

32.

Cescutti P. Bacterial capsular polysaccharides and exopolysaccharides. In: Holst O, Brennan PJ, von Itzstein M, Moran AP. Microbial glycobiology. Academic Press; 2010. pp. 93–108. [DOI]

33.

Zhou Y, Cui Y, Qu X. Exopolysaccharides of lactic acid bacteria: Structure, bioactivity and associations: A review. Carbohydr Polym. 2019;207:317–32. [DOI] [PubMed]

34.

Riaz Rajoka MS, Jin M, Haobin Z, Li Q, Shao D, Jiang C, et al. Functional characterization and biotechnological potential of exopolysaccharide produced by Lactobacillus rhamnosus strains isolated from human breast milk. LWT. 2018;89:638–47. [DOI]

35.

Zhang J, Xiao Y, Wang H, Zhang H, Chen W, Lu W. Lactic acid bacteria-derived exopolysaccharide: Formation, immunomodulatory ability, health effects, and structure-function relationship. Microbiol Res. 2023;274:127432. [DOI] [PubMed]

36.

Zhou X, Qi W, Hong T, Xiong T, Gong D, Xie M, et al. Exopolysaccharides from Lactobacillus plantarum NCU116 Regulate Intestinal Barrier Function via STAT3 Signaling Pathway. J Agric Food Chem. 2018;66:9719–27. [DOI] [PubMed]

37.

Riwes M, Reddy P. Short chain fatty acids: Postbiotics/metabolites and graft versus host disease colitis. Semin Hematol. 2020;57:1–6. [DOI] [PubMed] [PMC]

38.

Higashi B, Mariano TB, Filho BAdA, Gonçalves RAC, Oliveira AJBd. Effects of fructans and probiotics on the inhibition of Klebsiella oxytoca and the production of short-chain fatty acids assessed by NMR spectroscopy. Carbohydr Polym. 2020;248:116832. [DOI] [PubMed]

39.

Feng Y, Wang Y, Wang P, Huang Y, Wang F. Short-Chain Fatty Acids Manifest Stimulative and Protective Effects on Intestinal Barrier Function Through the Inhibition of NLRP3 Inflammasome and Autophagy. Cell Physiol Biochem. 2018;49:190–205. [DOI] [PubMed]

40.

Hosseini E, Grootaert C, Verstraete W, Wiele TVd. Propionate as a health-promoting microbial metabolite in the human gut. Nutr Rev. 2011;69:245–58. [DOI] [PubMed]

41.

Elfadil OM, Mundi MS, Abdelmagid MG, Patel A, Patel N, Martindale R. Butyrate: More Than a Short Chain Fatty Acid. Curr Nutr Rep. 2023;12:255–62. [DOI] [PubMed]

42.

Anjana, Tiwari SK. Bacteriocin-Producing Probiotic Lactic Acid Bacteria in Controlling Dysbiosis of the Gut Microbiota. Front Cell Infect Microbiol. 2022;12:851140. [DOI] [PubMed] [PMC]

43.

Lahiri D, Nag M, Dutta B, Sarkar T, Pati S, Basu D, et al. Bacteriocin: A natural approach for food safety and food security. Front Bioeng Biotechnol. 2022;10:1005918. [DOI] [PubMed] [PMC]

44.

Humam AM, Loh TC, Foo HL, Izuddin WI, Awad EA, Idrus Z, et al. Dietary Supplementation of Postbiotics Mitigates Adverse Impacts of Heat Stress on Antioxidant Enzyme Activity, Total Antioxidant, Lipid Peroxidation, Physiological Stress Indicators, Lipid Profile and Meat Quality in Broilers. Animals (Basel). 2020;10:982. [DOI] [PubMed] [PMC]

45.

Kim HS, Chae HS, Jeong SG, Ham JS, Im SK, Ahn CN, et al. In vitro Antioxidative Properties of Lactobacilli. J Anim Sci. 2005;19:262–5. [DOI]

46.

Kang C, Kim J, Park HM, Kim S, Paek N. Antioxidant activity and short-chain fatty acid production of lactic acid bacteria isolated from Korean individuals and fermented foods. 3 Biotech. 2021;11:217. [DOI] [PubMed] [PMC]

47.

McDonald AG, Tipton KF. Enzyme nomenclature and classification: the state of the art. FEBS J. 2023;290:2214–31. [DOI] [PubMed]

48.

Wardman JF, Bains RK, Rahfeld P, Withers SG. Carbohydrate-active enzymes (CAZymes) in the gut microbiome. Nat Rev Microbiol. 2022;20:542–56. [DOI] [PubMed]

49.

Simakachorn N, Pichaipat V, Rithipornpaisarn P, Kongkaew C, Tongpradit P, Varavithya W. Clinical evaluation of the addition of lyophilized, heat-killed Lactobacillus acidophilus LB to oral rehydration therapy in the treatment of acute diarrhea in children. J Pediatr Gastroenterol Nutr. 2000;30:68–72. [DOI] [PubMed]

50.

Andresen V, Gschossmann J, Layer P. Heat-inactivated Bifidobacterium bifidum MIMBb75 (SYN-HI-001) in the treatment of irritable bowel syndrome: a multicentre, randomised, double-blind, placebo-controlled clinical trial. Lancet Gastroenterol Hepatol. 2020;5:658–66. [DOI] [PubMed]

51.

Zeng P, Li J, Chen Y, Zhang L. The structures and biological functions of polysaccharides from traditional Chinese herbs. Prog Mol Biol Transl Sci. 2019;163:423–44. [DOI] [PubMed] [PMC]

52.

Lebrilla CB, Liu J, Widmalm G, Prestegard JH. Oligosaccharides and Polysaccharides. In: Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, et al., editors. Essentials of Glycobiology. 4th ed. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2022.

53.

Lovegrove A, Edwards CH, Noni ID, Patel H, El SN, Grassby T, et al. Role of polysaccharides in food, digestion, and health. Crit Rev Food Sci Nutr. 2017;57:237–53. [DOI] [PubMed] [PMC]

54.

Kaoutari AE, Armougom F, Gordon JI, Raoult D, Henrissat B. The abundance and variety of carbohydrate-active enzymes in the human gut microbiota. Nat Rev Microbiol. 2013;11:497–504. [DOI] [PubMed]

55.

Turnbaugh PJ, Ridaura VK, Faith JJ, Rey FE, Knight R, Gordon JI. The effect of diet on the human gut microbiome: a metagenomic analysis in humanized gnotobiotic mice. Sci Transl Med. 2009;1:6ra14. [DOI] [PubMed] [PMC]

56.

Zhang T, Yang Y, Liang Y, Jiao X, Zhao C. Beneficial Effect of Intestinal Fermentation of Natural Polysaccharides. Nutrients. 2018;10:1055. [DOI] [PubMed] [PMC]

57.

Huo J, Wu Z, Sun W, Wang Z, Wu J, Huang M, et al. Protective Effects of Natural Polysaccharides on Intestinal Barrier Injury: A Review. J Agric Food Chem. 2022;70:711–35. [DOI] [PubMed]

58.

Cian RE, Drago SR, Medina FSd, Martínez-Augustin O. Proteins and Carbohydrates from Red Seaweeds: Evidence for Beneficial Effects on Gut Function and Microbiota. Mar Drugs. 2015;13:5358–83. [DOI] [PubMed] [PMC]

59.

Li T, Huang S, Wang J, Yin P, Liu H, Sun C. Alginate oligosaccharides protect against fumonisin B1-induced intestinal damage via promoting gut microbiota homeostasis. Food Res Int. 2022;152:110927. [DOI] [PubMed]

60.

Rahman MA, Halfar J. First evidence of chitin in calcified coralline algae: new insights into the calcification process of Clathromorphum compactum. Sci Rep. 2014;4:6162. [DOI] [PubMed] [PMC]

61.

Štiglic AD, Kargl R, Beaumont M, Strauss C, Makuc D, Egger D, et al. Influence of Charge and Heat on the Mechanical Properties of Scaffolds from Ionic Complexation of Chitosan and Carboxymethyl Cellulose. ACS Biomater Sci Eng. 2021;7:3618–32. [DOI] [PubMed] [PMC]

62.

Yang Y, Liang M, Ouyang D, Tong H, Wu M, Su L. Research Progress on the Protective Effect of Brown Algae-Derived Polysaccharides on Metabolic Diseases and Intestinal Barrier Injury. Int J Mol Sci. 2022;23:10784. [DOI] [PubMed] [PMC]

63.

Iraha A, Chinen H, Hokama A, Yonashiro T, Kinjo T, Kishimoto K, et al. Fucoidan enhances intestinal barrier function by upregulating the expression of claudin-1. World J Gastroenterol. 2013;19:5500–7. [DOI] [PubMed] [PMC]

64.

Hwang P, Phan NN, Lu W, Hieu BTN, Lin Y. Low-molecular-weight fucoidan and high-stability fucoxanthin from brown seaweed exert prebiotics and anti-inflammatory activities in Caco-2 cells. Food Nutr Res. 2016;60:32033. [DOI] [PubMed] [PMC]

65.

Ranaldi G, Marigliano I, Vespignani I, Perozzi G, Sambuy Y. The effect of chitosan and other polycations on tight junction permeability in the human intestinal Caco-2 cell line. J Nutr Biochem. 2002;13:157–67. [DOI] [PubMed]

66.

Kootala S, Filho L, Srivastava V, Linderberg V, Moussa A, David L, et al. Reinforcing Mucus Barrier Properties with Low Molar Mass Chitosans. Biomacromolecules. 2018;19:872–82. [DOI] [PubMed]

67.

Xiong B, Liu M, Zhang C, Hao Y, Zhang P, Chen L, et al. Alginate oligosaccharides enhance small intestine cell integrity and migration ability. Life Sci. 2020;258:118085. [DOI] [PubMed]

68.

Mudgil D, Barak S, Khatkar BS. Guar gum: processing, properties and food applications-A Review. J Food Sci Technol. 2014;51:409–18. [DOI] [PubMed] [PMC]

69.

Rupert R, Rodrigues KF, Thien VY, Yong WTL. Carrageenan From Kappaphycus alvarezii (Rhodophyta, Solieriaceae): Metabolism, Structure, Production, and Application. Front Plant Sci. 2022;13:859635. [DOI] [PubMed] [PMC]

70.

Masarin F, Cedeno FRP, Chavez EGS, Oliveira LEd, Gelli VC, Monti R. Chemical analysis and biorefinery of red algae Kappaphycus alvarezii for efficient production of glucose from residue of carrageenan extraction process. Biotechnol Biofuels. 2016;9:122. [DOI] [PubMed] [PMC]

71.

Jayawardena TU, Nagahawatta DP, Fernando IPS, Kim Y, Kim J, Kim W, et al. A Review on Fucoidan Structure, Extraction Techniques, and Its Role as an Immunomodulatory Agent. Mar Drugs. 2022;20:755. [DOI] [PubMed] [PMC]

72.

Wang J, Zhang Q, Zhang Z, Song H, Li P. Potential antioxidant and anticoagulant capacity of low molecular weight fucoidan fractions extracted from Laminaria japonica. Int J Biol Macromol. 2010;46:6–12. [DOI] [PubMed]

73.

Yang C, Hsu H, Lee Y, Jan J, Chang S, Lin Y, et al. Natural fucoidans inhibit coronaviruses by targeting viral spike protein and host cell furin. Biochem Pharmacol. 2023;215:115688. [DOI] [PubMed]

74.

George A, Shrivastav PS. Fucoidan, a brown seaweed polysaccharide in nanodrug delivery. Drug Deliv Transl Res. 2023;13:2427–46. [DOI] [PubMed]

75.

Turrini E, Maffei F, Fimognari C. Ten Years of Research on Fucoidan and Cancer: Focus on Its Antiangiogenic and Antimetastatic Effects. Mar Drugs. 2023;21:307. [DOI] [PubMed] [PMC]

76.

Zahariev N, Katsarov P, Lukova P, Pilicheva B. Novel Fucoidan Pharmaceutical Formulations and Their Potential Application in Oncology-A Review. Polymers (Basel). 2023;15:3242. [DOI] [PubMed] [PMC]

77.

Thambiliyagodage C, Jayanetti M, Mendis A, Ekanayake G, Liyanaarachchi H, Vigneswaran S. Recent Advances in Chitosan-Based Applications-A Review. Materials (Basel). 2023;16:2073. [DOI] [PubMed] [PMC]

78.

Islam N, Hoque M, Taharat SF. Recent advances in extraction of chitin and chitosan. World J Microbiol Biotechnol. 2022;39:28. [DOI] [PubMed]

79.

Aranaz I, Alcántara AR, Civera MC, Arias C, Elorza B, Caballero AH, et al. Chitosan: An Overview of Its Properties and Applications. Polymers (Basel). 2021;13:3256. [DOI] [PubMed] [PMC]

80.

Hurtado A, Aljabali AAA, Mishra V, Tambuwala MM, Serrano-Aroca Á. Alginate: Enhancement Strategies for Advanced Applications. Int J Mol Sci. 2022;23:4486. [DOI] [PubMed] [PMC]

81.

Lee KY, Mooney DJ. Alginate: properties and biomedical applications. Prog Polym Sci. 2012;37:106–26. [DOI] [PubMed] [PMC]

82.

Mollah MZI, Zahid HM, Mahal Z, Faruque MRI, Khandaker MU. The Usages and Potential Uses of Alginate for Healthcare Applications. Front Mol Biosci. 2021;8:719972. [DOI] [PubMed] [PMC]

83.

Thombare N, Jha U, Mishra S, Siddiqui MZ. Guar gum as a promising starting material for diverse applications: A review. Int J Biol Macromol. 2016;88:361–72. [DOI] [PubMed]

84.

Alaeian MJ, Pourreza S, Yousefi M, Golalipour E, Setayesh L, Khosroshahi MZ, et al. The effects of guar gum supplementation on glycemic control, body mass and blood pressure in adults: A GRADE-assessed systematic review and meta-analysis of randomized clinical trials. Diabetes Res Clin Pract. 2023;199:110604. [DOI] [PubMed]

85.

Zhang N, Jin M, Wang K, Zhang Z, Shah NP, Wei H. Functional oligosaccharide fermentation in the gut: Improving intestinal health and its determinant factors-A review. Carbohydr Polym. 2022;284:119043. [DOI] [PubMed]

86.

Goh YJ, Klaenhammer TR. Genetic mechanisms of prebiotic oligosaccharide metabolism in probiotic microbes. Annu Rev Food Sci Technol. 2015;6:137–56. [DOI] [PubMed]

87.

Chen Y, Wen Y, Zhu Y, Chen Z, Mu W, Zhao C. Synthesis of bioactive oligosaccharides and their potential health benefits. Crit Rev Food Sci Nutr. 2023;21:1–13. [DOI] [PubMed]

88.

Jeong GW, Choi YS. Physicochemical Properties and Antioxidant Effects of Fucoidans Degraded by Hydrogen Peroxide under Electron Beam at Various Irradiation Doses. Appl Chem Eng. 2022;33:322–7. [DOI]

89.

Wang M, Veeraperumal S, Zhong S, Cheong K. Fucoidan-Derived Functional Oligosaccharides: Recent Developments, Preparation, and Potential Applications. Foods. 2023;12:878. [DOI] [PubMed] [PMC]

90.

Choi J, Kim H. Preparation of low molecular weight fucoidan by gamma-irradiation and its anticancer activity. Carbohydr Polym. 2013;97:358–62. [DOI] [PubMed]

91.

Wang L, Wang L, Cao C, Zhao J, Song C, Bao Z, et al. Chitosan and its oligosaccharide accelerate colonic motility and reverse serum metabolites in rats after excessive protein consumption. Int J Biol Macromol. 2023;253:127072. [DOI] [PubMed]

92.

Bi D, Yang X, Lu J, Xu X. Preparation and potential applications of alginate oligosaccharides. Crit Rev Food Sci Nutr. 2023;63:10130–47. [DOI] [PubMed]

93.

Kravchenko AO, Menchinskaya ES, Isakov VV, Glazunov VP, Yermak IM. Carrageenans and Their Oligosaccharides from Red Seaweeds Ahnfeltiopsis flabelliformis and Mastocarpus pacificus (Phyllophoraceae) and Their Antiproliferative Activity. Int J Mol Sci. 2023;24:7657. [DOI] [PubMed] [PMC]

94.

Sasaki D, Sasaki K, Abe A, Ozeki M, Kondo A. Effects of partially hydrolyzed guar gums of different molecular weights on a human intestinal in vitro fermentation model. J Biosci Bioeng. 2023;136:67–73. [DOI] [PubMed]

95.

Guzek A, Filipowski P, Rybicki Z, Grabski P, Gryszko L, Sopolińska E, et al. Bacteraemia caused by Lactobacillus casei in a patient after cardiac surgery. A case report. J Cardiothorac Surg. 2023;18:226. [DOI] [PubMed] [PMC]

96.

Mikucka A, Deptuła A, Bogiel T, Chmielarczyk A, Nurczyńska E, Gospodarek-Komkowska E, et al. Bacteraemia Caused by Probiotic Strains of Lacticaseibacillus rhamnosus-Case Studies Highlighting the Need for Careful Thought before Using Microbes for Health Benefits. Pathogens. 2022;11:977. [DOI] [PubMed] [PMC]

97.

Depommier C, Everard A, Druart C, Plovier H, Hul MV, Vieira-Silva S, et al. Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study. Nat Med. 2019;25:1096–103. [DOI] [PubMed] [PMC]

98.

Li Z, Hu G, Zhu L, Sun Z, Jiang Y, Gao M, et al. Study of growth, metabolism, and morphology of Akkermansia muciniphila with an in vitro advanced bionic intestinal reactor. BMC Microbiol. 2021;21:61. [DOI] [PubMed] [PMC]