Table Info

Table 3.

Summary of the recently published studies about the EGFR TK anticancer drugs-loaded Nanoparticulate formulations for the treatment of LC

Sr. No.	Drug	Nanoparticle formulation	Aim/Description	Year	Ref
1	Afatinib	Liposome	LPN modified with FD7 or CCD as a delivery platform was explored to enhance afatinib delivery across the BBB model of mouse brain-derived endothelial bEnd.3 cells.	2021	[63]
2	Osimertinib	Liposome vesicle	Liposome-based delivery of OSI can provide a new formulation of the drug that can be administered via alternative delivery routes (intravenous, inhalation).	2020	[64]
3	Gefitinib	Liposome	Gefitinib encapsulation based on nano liposome for enhancing curative effect of lung cancer	2020	[65]
4	Gefitinib	SLN	Preparation and evaluation of inhalable dry powder containing glucosamine-conjugated gefitinib SLNs for lung cancer therapy	2020	[66]
5	Gefitinib	Liposome	Liposomal gefitinib dry powder inhalers (LGDs) were prepared using the injection-lyophilization method	2020	[67]
6	Afatinib	Luminescence nanoparticles	Next-generation cancer-specific hybrid theranostic nanomaterials: MAGE-A3 NIR persistent luminescence nanoparticles conjugated to afatinib for in situ suppression of lung adenocarcinoma growth and metastasis	2020	[68]
8	Erlotinib	SLN	Co-encapsulated nanoparticles of Erlotinib and Quercetin for targeting lung cancer through nuclear EGFR and PI3K/AKT inhibition	2022	[69]
9	Erlotinib	Mesoporous silica nanoparticle	Injectable thermosensitive hydrogel containing erlotinib-loaded hollow mesoporous silica nanoparticles as a localized drug delivery system for NSCLC therapy	2020	[70]

LPN: lipid polymeric nanoparticle; BBB: blood brain barrier; SLN: solid lipid nanoparticle; EGFR: epidermal growth factor receptor; NSCLC: non-small cell lung cancer

Declarations

Acknowledgments

Authors are thankful to the Management of Dr Vishwanath Karad MIT-World Peace University, Kothrud, Pune 411038.

Author contributions

PSW: Writing—original draft, Data curation. ARC: Conceptualization, Writing—review & editing. KGR: Data curation, Validation, Visualization. BGP: Writing—review & editing. SCJ: Supervision, Validation.

Conflicts of interest

The authors declare no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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