Table Info

Table 4.

Some newer combinations of TKI

Sr. No.	Drug	Nanoparticle formulation	Description	Year	Ref
1	Icotinib & doxorubicin	EDS nanoparticle	In conclusion, the present study demonstrated that the use of synergistic NPs was effective for in vitro and in vivo targeted delivery and the inhibition of NSCLC and greatly enhanced the synergistic effect of doxorubicin and icotinib	2020	[71]
2	Erlotinib & bevacizumab	pH-sensitive lipid-polymer hybrid nanoparticles	Non-small cell lung cancer combination therapy: hyaluronic acid modified, epidermal growth factor receptor-targeted, pH-sensitive lipid-polymer hybrid nanoparticles for the delivery of erlotinib plus bevacizumab	2020	[72]
3	Erlotinib & bevacizumab	Magnetic nanoparticle	A multifunctional nanotheranostics agent potentiates erlotinib to EGFR wild-type non-small cell lung cancer	2022	[73]
4	Gefitinib & thymoquinone	PLGA nanoparticle	Delivery of gefitinib in synergism with thymoquinone via transferrin-conjugated nanoparticle sensitizes gefitinib-resistant non-small cell lung carcinoma to control metastasis and stemness	2021	[74]
5	Osimertinib & selumetinib	Micelle	Nanoparticles for co-delivery of osimertinib and selumetinib to overcome osimertinib-acquired resistance in non-small cell lung cancer	2021	[75]
6	Erlotinib & doxorubicin	Rhamnolipid-coated W/O/W double emulsion nanoparticles	RL-NP-DOX-ERL provided efficient delivery of doxorubicin and ERL to tumor tissue and successful tumor therapy with a synergetic effect	2021	[76]

NPs: nanoparticles; NSCLC: non-small cell lung cancer; EGFR: epidermal growth factor receptor; PLGA: polylactic-co-glycolic acid; RL-NP-DOX-ERL: rhamnolipid-coated double emulsion nanoparticles containing doxorubicin and erlotinib

Declarations

Acknowledgments

Authors are thankful to the Management of Dr Vishwanath Karad MIT-World Peace University, Kothrud, Pune 411038.

Author contributions

PSW: Writing—original draft, Data curation. ARC: Conceptualization, Writing—review & editing. KGR: Data curation, Validation, Visualization. BGP: Writing—review & editing. SCJ: Supervision, Validation.

Conflicts of interest

The authors declare no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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