Table Info

Table 3.

TP53 exon 5 frequency of known variants in Moroccan prostate cancer patients and their corresponding effects according to NCBI 1000 Genomes Browser and Human Genome Variation Society (HGVS) nomenclature

Effect	Variant ID	CDS change	Genome location	Protein change	Frequency, N = 48
Insertion	rs786202525	c.532_533insCCC	Chr17:7675079	p.Pro177_His178insPro	1 (2%)
Missense	rs1057519977	c.423C>G	Chr17:7675189	p.Cys141Trp	9 (19%)
Missense	rs1131691037	c.392A>T	Chr17:7675220	p.Asn131Ile	5 (10%)
Missense	rs138729528	c.523C>G	Chr17:7675089	p.Arg175Gly	5 (10%)
Missense	rs1555526335	c.377A>G	Chr17:7675235	p.Tyr126Cys	4 (8%)
Missense	rs758781593	c.408A>C	Chr17:7675204	p.Gln136His	4 (8%)
Missense	rs1555526226	c.439G>A	Chr17:7675173	p.Val147Ile	1 (2%)
Missense	rs28934875	c.412G>C	Chr17:7675200	p.Ala138Pro	1 (2%)
Missense	rs587782596	c.541C>A	Chr17:7675071	p.Arg181Ser	1 (2%)
Missense	rs730881999	c.380C>G	Chr17:7675232	p.Ser127Cys	1 (2%)
Missense	rs786203071	c.431A>C	Chr17:7675181	p.Gln144Pro	1 (2%)
NA	rs1321881901	c.559+31G>A	Chr17:7675022	NA	26 (54%)
NA	rs1032547645	c.559+22G>A	Chr17:7675031	NA	3 (6.25%)
NA	rs1221388024	c.376-4A>T	Chr17:7675240	NA	1 (2%)
NA	rs1466952182	c.376-51C>T	Chr17:7675287	NA	1 (2%)
NA	rs775915220	c.559+8G>A	Chr17:7675045	NA	1 (2%)
NA	rs786202799	c.376-2A>G	Chr17:7675238	NA	1 (2%)
Nonsene	rs757274881	c.430C>T	Chr17:7675182	p.Gln144Ter	1 (2%)
Synonymous	rs786203928	c.433C>T	Chr17:7675179	p.Leu145=	2 (4%)
Synonymous	rs1131691034	c.492G>A	Chr17:7675120	p.Lys164=	1 (2%)
Synonymous	rs761222871	c.468C>T	Chr17:7675144	p.Arg156=	1 (2%)
Synonymous	rs876659481	c.456G>A	Chr17:7675156	p.Pro152=	1 (2%)

CDS: coding DNA sequences

Declarations

Acknowledgments

Authors would like to thank the University Hassan II of Casablanca and the faculty of Sciences for all their efforts to support us during all the stages of this research. Thanks as well go to the team members of Laboratory: Virology, Oncology, Biosciences, Environment, and New BioEnergies of the FSTM. Many thanks to Mohammed V hospital in Rabat, Morocco for their help during sample collection.

Author contributions

KA: Conceptualization, Methodology, Formal analysis, Investigation, Project administration, Writing—original draft, Writing—review & editing. AL, RT, and KE: Resources. MME: Project administration, Validation, Writing—review & editing, Supervision. All authors read and approved the submitted version.

Conflicts of interest

The authors declare no conflicts of interest.

Ethical approval

The study protocol was approved by the Ethics Committee for Biomedical Research of the Faculty of Medicine and Pharmacy of Casablanca, Morocco (No. 3/2018/April 30/2018).

Consent to participate

The informed consent to participate in the study was obtained from all participants.

Consent to publication

Not applicable.

Availability of data and materials

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

Funding

Not applicable.

Copyright

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