Table Info

Table 5.

Prediction of the effects of novel missense variants on the TP53 protein by SIFT and PolyPhen 2.0 tools

CDS	Protein change	SIFT		Polyphen
CDS	Protein change	Score	Effect	Score	Effect
c.502C>A	p.His168Asn	0.02	Affect protein function	0.995	Probably damaging
c.382C>T	p.Pro128Ser	0.13	Tolerated	0.967	Probably damaging
c.398T>G	p.Met133Arg	0	Affect protein function	0.021	Benign
c.413C>G	p.Ala138Gly	0	Affect protein function	1	Probably damaging
c.457C>G	p.Pro153Ala	0.11	Tolerated	0.001	Benign
c.550G>C	p.Asp184His	0.03	Affect protein function	0.965	Probably damaging
c.376_377delinsCT	p.Tyr126Arg	0	Affect protein function	1	Probably damaging
c.427G>C	p.Val143Leu	0.09	Tolerated	0.466	Possibly damaging
c.428_429delinsG	p.Val143Ala	0	Affect protein function	1	Probably damaging
c.428T>A	p.Val143Glu	0	Affect protein function	1	Probably damaging
c.431_432delinsGG	p.Gln144Pro	0.04	Affect protein function	1	Probably damaging
c.432_433delinsCA	p.Gln144His	0.03	Affect protein function	0.999	Probably damaging
c.443A>T	p.Asp148Val	0.25	Tolerated	0.001	Benign
c.454C>A	p.Pro152Thr	0	Affect protein function	0.996	Probably damaging
c.461_462delinsAT	p.Gly154Asp	0.01	Affect protein function	1	Probably damaging
c.476C>A	p.Ala159Asp	0	Affect protein function	0.992	Probably damaging
c.490A>C	p.Lys164Gln	0	Affect protein function	0.998	Probably damaging
c.496T>G	p.Ser166Ala	0.44	Tolerated	0768	Possibly damaging

CDS: coding DNA sequences

Declarations

Acknowledgments

Authors would like to thank the University Hassan II of Casablanca and the faculty of Sciences for all their efforts to support us during all the stages of this research. Thanks as well go to the team members of Laboratory: Virology, Oncology, Biosciences, Environment, and New BioEnergies of the FSTM. Many thanks to Mohammed V hospital in Rabat, Morocco for their help during sample collection.

Author contributions

KA: Conceptualization, Methodology, Formal analysis, Investigation, Project administration, Writing—original draft, Writing—review & editing. AL, RT, and KE: Resources. MME: Project administration, Validation, Writing—review & editing, Supervision. All authors read and approved the submitted version.

Conflicts of interest

The authors declare no conflicts of interest.

Ethical approval

The study protocol was approved by the Ethics Committee for Biomedical Research of the Faculty of Medicine and Pharmacy of Casablanca, Morocco (No. 3/2018/April 30/2018).

Consent to participate

The informed consent to participate in the study was obtained from all participants.

Consent to publication

Not applicable.

Availability of data and materials

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

Funding

Not applicable.

Copyright

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