Table Info

Table 5.

Studies comparing aggressive hydration with lactate Ringer plus indomethacin: results

Author (country, year) [ref]	PEP (%) (experimental vs. control arm)	Severe PEP (%)	Hyperamylasemia (%)	Isolated pancreatic pain (%)	Fluid overload	Others SAE (serious adverse events between groups)	Pancreatic stent (%)
Mok et al. (USA, 2017) [47]	6 vs. 21 vs. 13 vs. 19	0 vs. 0 vs. 2 vs. 0	NA	NA	Only 1 patient in NSS + placebo group	None	21 vs. 31 vs. 25 vs. 31
Hajalikhani et al. (Iran, 2018) [48]	0.9 vs. 2.7 (p = 0.622)	No severe PEP in the groups	0.9 vs. 3.6 (p = 0.369)	NA	NA	NA	2.8 vs. 2.7
Thanage et al. (India, 2021) [49]	10.5 vs. 15.7 vs. 14.0	1 patient in diclofenac group	NA	NA	2 pts in LR + diclofenac arm 1 in LR arm	NA	10.5 vs. 7 vs. 3.5
Boal Carvalho et al. (Portugal, 2022) [50]	3.6 vs. 13.9 (p = 0.021)	0 vs. 6.9 (p = 0.020)	4.5 vs. 10.3	NA	None	None	16.9 vs. 16.7
Sperna Weiland et al. (Netherlands, 2021) [51]	8 vs. 9 (p = 0.53)	5 vs. 8 (p = 0.23)°, 1 vs. 2 (p = 0.089)^§	NA	NA	8 pts in experimental arm, 9 in control arm	None	6 vs. 6

^§ Atlanta Criteria; °: Cotton Criteria; LR: lactated Ringer’s; NA: not available; NSS: normal saline solution; PEP: post-ERCP acute pancreatitis; pts: patients

Supplementary materials

The supplementary materials for this article are available at: https://www.explorationpub.com/uploads/Article/file/1001247_sup_1.pdf.

Declarations

Author contributions

VGM: Conceptualization, Investigation, Writing—original draft, Writing—review & editing. AL: Conceptualization, Validation, Supervision, Writing—review & editing. SG and FF: Writing—review & editing. RS: Validation, Supervision. All authors read and approved the submitted version.

Conflicts of interest

Vincenzo Giorgio Mirante is the Editorial Board Member of Exploration of Medicine. Amedeo Lonardo is the Associate Editor of Exploration of Medicine. They had no involvement in the decision-making or the review process of this manuscript.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

The data analyzed in this study was obtained from PubMed (https://pubmed.ncbi.nlm.nih.gov). Requests for access to these datasets should be directed to Vincenzo Giorgio Mirante (v.mirante@libero.it).

Funding

Not applicable.

Copyright

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