Key studies investigating the relationship between hyperuricemia (HUA) and epiretinal pathologies
| Authors | Year | Objective | Findings | Implications |
|---|---|---|---|---|
| Thounaojam et al. [16] | 2019 | To examine the contribution of monosodium urate to retinal inflammation in diabetic retinopathy | Monosodium urate crystals promoted retinal inflammation and progression of diabetic retinopathy | Points to the inflammatory role of urate crystals in retinal diseases, advocating for anti-inflammatory treatments in hyperuricemic patients |
| Pai et al. [8] | 2022 | To examine the effects of short-term HUA on retinal structure in mice | HUA led to structural retinal changes, which were reversible with uric acid-lowering agents | Indicates potential benefits of early intervention with uric acid-lowering therapy to prevent retinal damage |
| Qin et al. [13] | 2022 | To investigate the role of uric acid in diabetic macular edema | Elevated uric acid in aqueous humor was identified as a risk factor for diabetic macular edema in type 2 diabetes patients | Suggests monitoring and managing uric acid levels in diabetic patients to reduce the risk of macular edema |
| Lu et al. [15] | 2022 | To study the relationship between serum uric acid and retinal microvasculature using optical coherence tomography angiography | High serum uric acid was correlated with microvasculature deficits in the retina | Reinforces the importance of controlling uric acid levels to preserve retinal vascular health |
| Wei et al. [14] | 2023 | To evaluate biomarkers for diabetic retinopathy complicated with HUA | Serum VEGF, high-sensitivity CRP, and cystatin-C levels were useful in diagnosing diabetic retinopathy with HUA | Supports the use of these biomarkers in clinical practice to improve the diagnosis and management of retinopathy |
| Su et al. [25] | 2023 | To explore the sex differences in the relationship between obesity-related indices and HUA | HUA was linked to obesity-related indices, with differences observed between sexes | Highlights the need for sex-specific approaches in managing HUA to prevent related ocular complications |
This table synthesizes key findings from various studies, demonstrating the multifaceted relationship between HUA and epiretinal pathologies, and underscores the importance of managing uric acid levels to prevent and mitigate retinal diseases. VEGF: vascular endothelial growth factor; CRP: C-reactive protein
