Table Info

Table 5.

Randomized clinical trial evaluating ertugliflozin

Study name	Sample	Duration	Outcome	Adverse drug events		Reference
Study name	Sample	Duration	Outcome	Common	Uncommon	Reference
Evaluation of Ertugliflozin Efficacy and Safety Cardiovascular Outcomes Trial (VERTIS CV)	8,246 participants	3.5 years	Ertugliflozin was determined to be as effective as a placebo in relation to the combined outcome of cardiovascular death, non-fatal heart attack, or non-fatal stroke, within the established non-inferiority margin	Urinary tract infection, symptomatic hypoglycemia	Male and female mycotic infection of genitals, severe hypoglycemia, hypovolemia, acute kidney injury, pancreatitis, diabetic ketoacidosis, fracture, amputation	[79]
Evaluation of Ertugliflozin effIcacy and Safety (VERTIS FACTORIAL)	1,233 participants	52 weeks	When administered alongside metformin in patients with poorly managed type 2 diabetes, the combined use of ertugliflozin and sitagliptin resulted in superior glycaemic control over 52 weeks compared to each medication alone	Genital mycotic infections, urinary tract infection	hypovolemia, hypoglycemia	[80]

Declarations

Author contributions

FH, HN: Conceptualization, Investigation, Writing—original draft. DS: Writing—original draft. M Arshad: Investigation, Writing—original draft. SZ: Investigation, Writing—review & editing. MKR: Investigation. MAH, M Akhtar: Writing—review & editing. AKN: Supervision. All authors reviewed and approved the final version of the manuscript.

Conflicts of interest

The authors have no conflicts of interest to declare.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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