Table Info

Table 1.

Summary of the discussed metastatic processes of breast cancer affected by various transcription factors

Transcription factor	Metastatic process affected
Transcription factor	Angiogenesis/Vascularization	EMT/MET	Migration	Invasion	Cell cycle/Apoptosis
E2F	√			√	√
HIF	√	√		√
EMT master regulators		√	√	√	√
SOX	√	√	√	√
ETS	√	√	√	√	√
YY1	√
FoxM1		√	√	√
Bach1	√		√	√
SIX	√	√
RUNX				√
MYC	√				√
KLFs		√	√	√	√
c-Jun			√		√

EMT: epithelial-mesenchymal transition; MET: mesenchymal-epithelial transition; HIF: hypoxia-inducible factor; SOX: sex determining region Y-related high-mobility group box; ETS: E26 transformation-specific; YY1: Yin Yang 1; FoxM1: forkhead box M1; Bach1: BTB domain and CNC homology 1; SIX: sineoculis homeobox homolog; MYC: myelocytomatosis; KLFs: Kruppel-like factors; RUNX: runt-related transcription factor

Declarations

Author contributions

SM: Conceptualization, Investigation, Visualization, Writing—original draft, Writing—review & editing. CM: Conceptualization, Funding acquisition, Supervision. YL: Project administration, Validation, Supervision. All authors read and approved the submitted version.

Conflicts of interest

The authors declare that there are no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

This paper was funded by The Assisi Foundation of Memphis, Brown, Chester, PhD (PI). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Copyright

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