Variables associated with non-adherence
Variable | B | Standard error | p-value | Odds ratio (95% CI) |
---|---|---|---|---|
Age (dichotomized)* | 1.31 | 0.26 | < 0.001 | 3.72 (2.23–6.22) |
Non-European ethnicity | 1.18 | 0.37 | 0.002 | 3.26 (1.57–6.76) |
Number of AH pills | 0.23 | 0.10 | 0.015 | 1.26 (1.05–1.52) |
Use of ARB | –0.60 | 0.30 | 0.046 | 0.55 (0.31–0.99) |
* Youngest quartile (Q1) compared to other three quartiles (Q2–Q4) dichotomized. Use of ARB; compared to other antihypertensive medications dichotomized. B: beta; CI: confidence intervals; AH: antihypertensive; ARB: angiotensin receptor blocker
The authors thank the patients who participated in the study and the physicians who referred them.
EO: Investigation, Formal analysis, Writing—original draft. LVH and KMB: Investigation, Data curation. SR, AA, and OUB: Investigation. VNK: Investigation, Data curation, Validation. KL: Supervision. MDS, RM, EG, SEK, and AH: Project administration, Writing—review & editing. MR: Project administration. MSO: Methodology, Investigation. ACKL: Project administration, Data curation, Formal Analysis, Writing—review & editing, Funding acquisition. CLS: Project administration, Formal Analysis, Writing—review & editing, Supervision, Funding acquisition.
Marit D. Solbu has received honoraria from AstraZeneca, Novartis, Bayer and Boehringer-Ingelheim. Sverre E. Kjeldsen reports lecture honoraria from Emcure, Getz, Glenmark, J.B. Pharma, Merck Healthcare KGaA, and Vector-Intas in the past 3 years. Sverre E. Kjeldsen is the Guest Editor of Exploration of Medicine but had no involvement in the decision-making or the review process of this manuscript. Aud Høieggen reports lecture honoraria from AstraZeneca. The other authors declare that there are no conflicts of interest.
The study was approved by the Regional Ethical Committee of the UiT Arctic University in Norway, Tromsø, Norway (approval no. 2017/804/REK Nord) and complies with the Declaration of Helsinki.
All participants signed written informed consent.
Not applicable.
Requests to the corresponding author in dire need.
The study was supported by grants from the Research Council of Norway [273563], the South-East Norwegian Regional Health Authority, the University of Oslo, Oslo University Hospital, Ullevaal, and the North Norwegian Regional Health Authority. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
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