Recommendations from the European Society of Hypertension and European Society of Cardiology to improve drug adherence in hypertensive patients (from [11])
Level of action
Recommendations
Physician level
Provide information on the risks of hypertension and the benefits of treatment, as well as agreeing on a treatment strategy to achieve and maintain blood pressure control using lifestyle measures and a single-pill-based treatment strategy when possible (information material, programmed learning, and computer-aided counseling)
Empowerment of the patient
Feedback on behavioral and clinical improvements
Assessment and resolution of individual barriers to adherence
Collaboration with other healthcare providers, especially nurses and pharmacists
Patient level
Self-monitoring of blood pressure (including telemonitoring)
Group sessions
Instruction combined with motivational strategies
Self-management with simple patient-guided systems
Use of reminders
Obtain family, social, or nurse support
Provision of drugs at worksite
Treatment level
Simplification of the drug regimen favoring the use of single-pill therapy
Reminder packaging
Health system level
Supporting the development of monitoring systems (telephone follow-up, home visits, telemonitoring of home blood pressure, and electronic health records)
Financially supporting the collaboration between healthcare providers (e.g., pharmacists and nurses)
Reimbursement of single-pill combination pills
Development of national databases, including prescription data, available for physicians and pharmacists
Open Exploration maintains a neutral stance on jurisdictional claims in published institutional affiliations and maps. All opinions expressed in this article are the personal views of the author(s) and do not represent the stance of the editorial team or the publisher.
References
NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants.Lancet. 2021;398:957–80. [DOI] [PubMed] [PMC]
Lee EKP, Poon P, Yip BHK, Bo Y, Zhu MT, Yu CP, et al. Global Burden, Regional Differences, Trends, and Health Consequences of Medication Nonadherence for Hypertension During 2010 to 2020: A Meta-Analysis Involving 27 Million Patients.J Am Heart Assoc. 2022;11:e026582. [DOI] [PubMed] [PMC]
Bergland OU, Halvorsen LV, Søraas CL, Hjørnholm U, Kjær VN, Rognstad S, et al. Detection of Nonadherence to Antihypertensive Treatment by Measurements of Serum Drug Concentrations.Hypertension. 2021;78:617–28. [DOI] [PubMed]
Hamdidouche I, Jullien V, Boutouyrie P, Billaud E, Azizi M, Laurent S. Routine urinary detection of antihypertensive drugs for systematic evaluation of adherence to treatment in hypertensive patients.J Hypertens. 2017;35:1891–8. [DOI] [PubMed]
Burnier M, Egan BM. Adherence in Hypertension: A Review of Prevalence, Risk Factors, Impact, and Management.Circ Res. 2019;124:1124–40. [DOI] [PubMed]
Robberechts T, Stoenoiu MS, Burnier M, Persu A. Optimizing drug adherence in hypertension: More than a mind game.Kardiol Pol. 2024;82:259–66. [DOI] [PubMed]
Abegaz TM, Shehab A, Gebreyohannes EA, Bhagavathula AS, Elnour AA. Nonadherence to antihypertensive drugs: A systematic review and meta-analysis.Medicine (Baltimore). 2017;96:e5641. [DOI] [PubMed] [PMC]
Darricarrere C, Jacquot E, Bricout S, Louis C, Bénard M, Poulter NR. Uncontrolled blood pressure and therapeutic inertia in treated hypertensive patients: A retrospective cohort study using a UK general practice database.J Clin Hypertens (Greenwich). 2023;25:895–904. [DOI] [PubMed] [PMC]
Milman T, Joundi RA, Alotaibi NM, Saposnik G. Clinical inertia in the pharmacological management of hypertension: A systematic review and meta-analysis.Medicine (Baltimore). 2018;97:e11121. [DOI] [PubMed] [PMC]
Zheutlin AR, Mondesir FL, Derington CG, King JB, Zhang C, Cohen JB, et al. Analysis of Therapeutic Inertia and Race and Ethnicity in the Systolic Blood Pressure Intervention Trial: A Secondary Analysis of a Randomized Clinical Trial.JAMA Netw Open. 2022;5:e2143001. [DOI] [PubMed] [PMC]
Williams B, Mancia G, Spiering W, Agabiti Rosei E, Azizi M, Burnier M, et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension.J Hypertens. 2018;36:1953–2041. [DOI] [PubMed]
Unger T, Borghi C, Charchar F, Khan NA, Poulter NR, Prabhakaran D, et al. 2020 International Society of Hypertension global hypertension practice guidelines.J Hypertens. 2020;38:982–1004. [DOI] [PubMed]
Mancia G, Kreutz R, Brunström M, Burnier M, Grassi G, Januszewicz A, et al. 2023 ESH Guidelines for the management of arterial hypertension The Task Force for the management of arterial hypertension of the European Society of Hypertension: Endorsed by the International Society of Hypertension (ISH) and the European Renal Association (ERA).J Hypertens. 2023;41:1874–2071. [DOI] [PubMed]
Whelton PK, Carey RM, Aronow WS, Casey DE Jr, Collins KJ, Dennison Himmelfarb C, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.Hypertension. 2018;71:e13–115. [DOI] [PubMed]
Egan BM, Kjeldsen SE, Narkiewicz K, Kreutz R, Burnier M. Single-pill combinations, hypertension control and clinical outcomes: potential, pitfalls and solutions.Blood Press. 2022;31:164–8. [DOI] [PubMed]
Pathak A, Poulter NR, Kavanagh M, Kreutz R, Burnier M. Improving the Management of Hypertension by Tackling Awareness, Adherence, and Clinical Inertia: A Symposium Report.Am J Cardiovasc Drugs. 2022;22:251–61. [DOI] [PubMed] [PMC]
Parati G, Kjeldsen S, Coca A, Cushman WC, Wang J. Adherence to Single-Pill Versus Free-Equivalent Combination Therapy in Hypertension: A Systematic Review and Meta-Analysis.Hypertension. 2021;77:692–705. [DOI] [PubMed]
McEvoy JW, McCarthy CP, Bruno RM, Brouwers S, Canavan MD, Ceconi C, et al.; ESC Scientific Document Group. 2024 ESC Guidelines for the management of elevated blood pressure and hypertension: Developed by the task force on the management of elevated blood pressure and hypertension of the European Society of Cardiology (ESC) and endorsed by the European Society of Endocrinology (ESE) and the European Stroke Organisation (ESO).Eur Heart J. 2024;45:3912–4018. [DOI] [PubMed]
Abdalla M, Bolen SD, Brettler J, Egan BM, Ferdinand KC, Ford CD, et al.; American Heart Association and American Medical Association. Implementation Strategies to Improve Blood Pressure Control in the United States: A Scientific Statement From the American Heart Association and American Medical Association.Hypertension. 2023;80:e143–57. [DOI] [PubMed] [PMC]
Victor RG, Blyler C, Elashoff RM. A Trial of Blood-Pressure Reduction in Black Barbershops.N Engl J Med. 2018;379:200–1. [DOI] [PubMed]
Victor RG, Lynch K, Li N, Blyler C, Muhammad E, Handler J, et al. A Cluster-Randomized Trial of Blood-Pressure Reduction in Black Barbershops.N Engl J Med. 2018;378:1291–301. [DOI] [PubMed] [PMC]
Boivin JM, Risse J, Laurière E, Burnier M. Screening for hypertension at the hairdresser: a feasibility study in France and Morocco.Blood Press. 2020;29:202–8. [DOI] [PubMed]
Schoenthaler AM, Lancaster KJ, Chaplin W, Butler M, Forsyth J, Ogedegbe G. Cluster Randomized Clinical Trial of FAITH (Faith-Based Approaches in the Treatment of Hypertension) in Blacks: Main Trial Results.Circ Cardiovasc Qual Outcomes. 2018;11:e004691. [DOI] [PubMed]
Santschi V, Chiolero A, Burnand B, Colosimo AL, Paradis G. Impact of pharmacist care in the management of cardiovascular disease risk factors: a systematic review and meta-analysis of randomized trials.Arch Intern Med. 2011;171:1441–53. [DOI] [PubMed]
Blyler CA, Ebinger J, Rashid M, Moy NP, Cheng S, Albert CM, et al. Improving Efficiency of the Barbershop Model of Hypertension Care for Black Men With Virtual Visits.J Am Heart Assoc. 2021;10:e020796. [DOI] [PubMed] [PMC]
Blyler CA, Rader F. Sustainability of blood pressure reduction in black barbershops.Curr Opin Cardiol. 2019;34:693–9. [DOI] [PubMed] [PMC]
Bryant KB, Moran AE, Kazi DS, Zhang Y, Penko J, Ruiz-Negrón N, et al. Cost-Effectiveness of Hypertension Treatment by Pharmacists in Black Barbershops.Circulation. 2021;143:2384–94. [DOI] [PubMed] [PMC]
Bryant KB, Rao AS, Cohen LP, Dandan N, Kronish IM, Barai N, et al. Effectiveness and Cost-Effectiveness of Team-Based Care for Hypertension: A Meta-Analysis and Simulation Study.Hypertension. 2023;80:1199–208. [DOI] [PubMed] [PMC]
Choi BC, Pak AW. Multidisciplinarity, interdisciplinarity and transdisciplinarity in health research, services, education and policy: 1. Definitions, objectives, and evidence of effectiveness.Clin Invest Med. 2006;29:351–64. [PubMed]
Celio J, Ninane F, Bugnon O, Schneider MP. Pharmacist-nurse collaborations in medication adherence-enhancing interventions: A review.Patient Educ Couns. 2018;101:1175–92. [DOI] [PubMed]
Chaturvedi A, Zhu A, Gadela NV, Prabhakaran D, Jafar TH. Social Determinants of Health and Disparities in Hypertension and Cardiovascular Diseases.Hypertension. 2024;81:387–99. [DOI] [PubMed] [PMC]
Hahad O, Rajagopalan S, Lelieveld J, Sørensen M, Frenis K, Daiber A, et al. Noise and Air Pollution as Risk Factors for Hypertension: Part I—Epidemiology.Hypertension. 2023;80:1375–83. [DOI] [PubMed] [PMC]
Will KK, Johnson ML, Lamb G. Team-Based Care and Patient Satisfaction in the Hospital Setting: A Systematic Review.J Patient Cent Res Rev. 2019;6:158–71. [DOI] [PubMed] [PMC]
Carter BL, Rogers M, Daly J, Zheng S, James PA. The potency of team-based care interventions for hypertension: a meta-analysis.Arch Intern Med. 2009;169:1748–55. [DOI] [PubMed] [PMC]
Clark CE, Smith LF, Taylor RS, Campbell JL. Nurse led interventions to improve control of blood pressure in people with hypertension: systematic review and meta-analysis.BMJ. 2010;341:c3995. [DOI] [PubMed] [PMC]
Mills KT, Obst KM, Shen W, Molina S, Zhang HJ, He H, et al. Comparative Effectiveness of Implementation Strategies for Blood Pressure Control in Hypertensive Patients: A Systematic Review and Meta-analysis.Ann Intern Med. 2018;168:110–20. [DOI] [PubMed] [PMC]
Nieuwlaat R, Wilczynski N, Navarro T, Hobson N, Jeffery R, Keepanasseril A, et al. Interventions for enhancing medication adherence.Cochrane Database Syst Rev. 2014;2014:CD000011. [DOI] [PubMed] [PMC]
Ogungbe O, Byiringiro S, Adedokun-Afolayan A, Seal SM, Dennison Himmelfarb CR, Davidson PM, et al. Medication Adherence Interventions for Cardiovascular Disease in Low- and Middle-Income Countries: A Systematic Review.Patient Prefer Adherence. 2021;15:885–97. [DOI] [PubMed] [PMC]
Ogungbe O, Cazabon D, Ajenikoko A, Jeemon P, Moran AE, Commodore-Mensah Y. Determining the frequency and level of task-sharing for hypertension management in LMICs: A systematic review and meta-analysis.EClinicalMedicine. 2022;47:101388. [DOI] [PubMed] [PMC]
Pasha M, Brewer LC, Sennhauser S, Alsawas M, Murad MH. Health Care Delivery Interventions for Hypertension Management in Underserved Populations in the United States: A Systematic Review.Hypertension. 2021;78:955–65. [DOI] [PubMed]
Proia KK, Thota AB, Njie GJ, Finnie RK, Hopkins DP, Mukhtar Q, et al. Team-based care and improved blood pressure control: a community guide systematic review.Am J Prev Med. 2014;47:86–99. [DOI] [PubMed] [PMC]
Santschi V, Chiolero A, Colosimo AL, Platt RW, Taffé P, Burnier M, et al. Improving blood pressure control through pharmacist interventions: a meta-analysis of randomized controlled trials.J Am Heart Assoc. 2014;3:e000718. [DOI] [PubMed] [PMC]
Baral N, Volgman AS, Seri A, Chelikani V, Isa S, Javvadi SLP, et al. Adding Pharmacist-Led Home Blood Pressure Telemonitoring to Usual Care for Blood Pressure Control: A Systematic Review and Meta-Analysis.Am J Cardiol. 2023;203:161–8. [DOI] [PubMed]
Lee JK, Grace KA, Taylor AJ. Effect of a pharmacy care program on medication adherence and persistence, blood pressure, and low-density lipoprotein cholesterol: a randomized controlled trial.JAMA. 2006;296:2563–71. [DOI] [PubMed]
Hunt JS, Siemienczuk J, Pape G, Rozenfeld Y, MacKay J, LeBlanc BH, et al. A randomized controlled trial of team-based care: impact of physician-pharmacist collaboration on uncontrolled hypertension.J Gen Intern Med. 2008;23:1966–72. [DOI] [PubMed] [PMC]
Dixon DL, Sisson EM, Parod ED, Van Tassell BW, Nadpara PA, Carl D, et al. Pharmacist-physician collaborative care model and time to goal blood pressure in the uninsured population.J Clin Hypertens (Greenwich). 2018;20:88–95. [DOI] [PubMed] [PMC]
Hinneh T, Boakye H, Metlock F, Ogungbe O, Kruahong S, Byiringiro S, et al. Effectiveness of team-based care interventions in improving blood pressure outcomes among adults with hypertension in Africa: a systematic review and meta-analysis.BMJ Open. 2024;14:e080987. [DOI] [PubMed] [PMC]
Benson G, Hayes J, Bunkers-Lawson T, Sidebottom A, Boucher J. Leveraging Registered Dietitian Nutritionists and Registered Nurses in Medication Management to Reduce Therapeutic Inertia.Diabetes Spectr. 2022;35:491–503. [DOI] [PubMed] [PMC]
Burnier M. Poor Physician Adherence to Clinical Guidelines in Hypertension—Time for Physicians to Face Clinical Inertia.JAMA Netw Open. 2024;7:e2426830. [DOI] [PubMed]
Nakanishi M, Mizuno T, Mizokami F, Koseki T, Takahashi K, Tsuboi N, et al. Impact of pharmacist intervention for blood pressure control in patients with chronic kidney disease: A meta-analysis of randomized clinical trials.J Clin Pharm Ther. 2021;46:114–20. [DOI] [PubMed]
Jafar TH, Shirore RM. Team-Based Care With Nonphysician Titration of Antihypertensive Medications in Collaboration With Physicians: A Cost-Effective Way to Control Blood Pressure?Hypertension. 2023;80:1209–12. [DOI] [PubMed]
Nickel WK, Weinberger SE, Guze PA; Patient Partnership in Healthcare Committee of the American College of Physicians; Carney J, Ende J, Hoy E, Myerson S, Rothholz M, Sands D, et al. Principles for Patient and Family Partnership in Care: An American College of Physicians Position Paper.Ann Intern Med. 2018;169:796–9. [DOI] [PubMed]
Murry LT, Kennelty K. Opportunity for Pharmacists in Telehealth, Team-Based Care: Clinical Inertia.Telemed J E Health. 2020;26:1199–201. [DOI] [PubMed] [PMC]
Ishak AM, Mukamal KJ, Wood JM, Vyavahare M, Cluett JL, Juraschek SP. Pharmacist-led rapid medication titration for hypertension management by telehealth: A quality improvement initiative.J Clin Hypertens (Greenwich). 2024;26:217–20. [DOI] [PubMed] [PMC]
Jacob V, Reynolds JA, Chattopadhyay SK, Nowak K, Hopkins DP, Fulmer E, et al. Economics of Team-Based Care for Blood Pressure Control: Updated Community Guide Systematic Review.Am J Prev Med. 2023;65:735–54. [DOI] [PubMed] [PMC]
Bandiera C, Cardoso E, Locatelli I, Zaman K, Diciolla A, Digklia A, et al. A pharmacist-led interprofessional medication adherence program improved adherence to oral anticancer therapies: The OpTAT randomized controlled trial.PLoS One. 2024;19:e0304573. [DOI] [PubMed] [PMC]
Lelubre M, Clerc O, Grosjean M, Amighi K, De Vriese C, Bugnon O, et al. Implementation study of an interprofessional medication adherence program for HIV patients in Switzerland: quantitative and qualitative implementation results.BMC Health Serv Res. 2018;18:874. [DOI] [PubMed] [PMC]
Lelubre M, Kamal S, Genre N, Celio J, Gorgerat S, Hugentobler Hampai D, et al. Interdisciplinary Medication Adherence Program: The Example of a University Community Pharmacy in Switzerland.Biomed Res Int. 2015;2015:103546. [DOI] [PubMed] [PMC]