Timetable of radiological imaging and biopsy reports over the time from disease detection
| Date | Imaging/Procedure | Summary |
|---|---|---|
| 17/03/2022 | Breast US | Dense glandular tissue, fibrocystic mastopathy. Suspicious left axillary lymph node (22 × 20 mm). |
| 18/03/2022 | Mammography | Dense parenchyma with nodular aspects, no pathological calcifications. Axillary lymph nodes present. |
| 07/04/2022 | Axillary core biopsy | Poorly differentiated carcinoma with squamous features. |
| 19/04/2022 | Breast MRI | Large heterogeneous lesion in left breast (> 42 mm), enlarged left axillary lymph node (> 45 mm), BIRADS 5. |
| 19/04/2022 | Full-body CT scan | Enlarged left axillary lymph nodes, small liver and ovarian cysts, mild left pleural effusion. |
| 18/05/2022 | PET scan | Pathological hyperaccumulation in left breast (SUVmax 6.3), bilateral lymph node involvement. Indeterminate pelvic lesion. |
| 20/05/2022 | Abdomen US | Hepatomegaly with small angioma (5 mm), distended gallbladder, no peritoneal fluid. |
| 01/06/2022 | Mammary and axillary biopsy | High-grade invasive carcinoma (ER–/PR–/HER2–, Ki-67 40%). Lymph node involvement confirmed. |
| 14/08/2022–06/03/2023 | Neoadjuvant chemotherapy | Carboplatin/paclitaxel + pembrolizumab (12 cycles), followed by epirubicin/cyclophosphamide + pembrolizumab (4 cycles). |
| 12/12/2022 | Mammography | Reduction in left breast mass (19 mm vs 33 mm), persistent axillary lymphadenopathy. |
| 09/12/2022 | Full-body CT scan | Stable mammary and lymph node lesions. Ascending aortic aneurysm (42 mm). |
| 13/03/2023 | Abdomen US | Small gallbladder adenomyoma (5 mm). |
| 14/03/2023 | Breast US | Left fibroadenoma (15 mm), reactive axillary lymphadenopathy bilaterally. |
| 27/03/2023 | PET scan | Stable left breast lesion improved axillary lymph nodes. |
| 29/03/2023 | Breast MRI | Persistent left breast nodules (12 mm vs 15 mm), BIRADS 6. |
| 14/04/2023 | Left total mastectomy and axillary dissection | Fibrocystic changes. Negative margins. 10 lymph nodes disease-free. Pathological stage: ypT0N0. |
| 29/06/2023–18/07/2023 | Radiotherapy | 42.56 Gy to left breast, supraclavicular/subclavian nodes, and internal mammary chain. Mild skin toxicity (G1). |
| 29/06/2023–04/08/2023 | Immunotherapy | Pembrolizumab. |
| 14/10/2023 | Breast US | Post-mastectomy changes. Right breast with cystic and dysplastic nodules. Normal lymph nodes. |
| 24/10/2023 | Full-body CT scan | Mild pulmonary changes, left mastectomy without recurrence, hepatomegaly. |
US: ultrasound; BIRADS: breast imaging reporting and data system
