Table Info

Table 3.

Inter- and intra-group comparisons, mean and standard deviation values of modified Xerostomia Quality of Life Scale (XeQoLS) questionnaire part 1 [8]

Domain	Question	Interval	Quality of life score (Mean ± SD)		p-value
Domain	Question	Interval	Group A	Group B	p-value
1. Physical functioning	1.1 Do you have difficulty chewing because of your dry mouth?	Baseline	61.30 ± 25.28	57.71 ± 27.35	0.416^ns
		After 2 weeks	32.17 ± 25.58	31.25 ± 25.25	0.885^ns
		p-value	< 0.001*	< 0.001*	-
	1.2 Do you have difficulty swallowing because of your dry mouth?	Baseline	51.30 ± 41.26	53.75 ± 42.00	0.307^ns
		After 2 weeks	40.43 ± 39.02	39.17 ± 39.00	0.809^ns
		p-value	0.006*	0.006*	-
	1.3 Is speech difficult because of your dry mouth?	Baseline	56.09 ± 30.41	55.00 ± 31.76	0.307^ns
		After 2 weeks	29.78 ± 27.16	30.62 ± 28.14	0.487^ns
		p-value	< 0.001*	< 0.001*	-
	1.4 Is taste affected by your dry mouth?	Baseline	30.00 ± 30.90	28.75 ± 30.83	0.999^ns
		After 2 weeks	23.48 ± 29.79	20.00 ± 27.50	0.266^ns
		p-value	0.012*	0.013*	-
2. Pain/discomfort	2.1 How dry is your mouth?	Baseline	72.61 ± 24.16	70.83 ± 27.81	0.589^ns
		After 2 weeks	29.13 ± 20.43	29.58 ± 19.89	0.784^ns
		p-value	< 0.001*	< 0.001*	-
	2.2 Do you have a burning sensation in your mouth?	Baseline	29.13 ± 30.88	29.58 ± 29.85	0.445^ns
		After 2 weeks	14.35 ± 20.41	13.75 ± 20.18	0.328^ns
		p-value	0.002*	0.002*	-
3. Other clinical acceptances	3.1 Do you have difficulty with sleeping caused by your dry mouth?	Baseline	57.83 ± 25.40	52.50 ± 23.08	0.233^ns
		After 2 weeks	25.87 ± 20.92	22.92 ± 22.93	0.501^ns
		p-value	< 0.001*	< 0.001*	-
	3.2 How often do you sip liquids for oral comfort when not eating?	Baseline	59.78 ± 22.59	56.88 ± 24.58	0.607^ns
		After 2 weeks	31.74 ± 20.54	26.88 ± 21.46	0.208^ns
		p-value	< 0.001*	< 0.001*	-

* significant (p < 0.05). ns: non-significant (p > 0.05); SD: standard deviation. -: no data

Declarations

Acknowledgments

The authors would like to thank Dr. Mohamed Zaki, lecturer of pharmaceuticals in the Faculty of Pharmacy at Al Azhar University, Cairo, Egypt, for preparing both the study and control treatment.

Author contributions

AM: Conceptualization, Formal analysis, Investigation, Resources, Writing—original draft. BE: Conceptualization, Data curation, Methodology, Project administration, Supervision, Validation, Visualization, Writing—review & editing. ME: Methodology, Project administration, Supervision, Validation. WAE: Conceptualization, Data curation. ST: Methodology, Project administration, Validation, Visualization. MZ: Conceptualization, Data curation, Methodology, Project administration, Supervision, Validation, Writing—review & editing. All authors read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

The study was performed following the Declaration of Helsinki, and the protocol was approved by the Research Ethics Committee in the Faculty of Dentistry at Cairo University [approval no 16 2 20]. The trial is registered on clinicaltrials.gov, identifier: NCT04252209.

Consent to participate

Informed consent to participate in the study was obtained from all participants.

Consent to publication

Not applicable.

Availability of data and materials

The datasets used and/or analyses used during the current study are available from the corresponding author upon reasonable request.

Funding

Not applicable.

Copyright

Publisher’s note

Open Exploration maintains a neutral stance on jurisdictional claims in published institutional affiliations and maps. All opinions expressed in this article are the personal views of the author(s) and do not represent the stance of the editorial team or the publisher.

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