Comparison of the significances of some mechanisms involved in transport of calcium, sodium, and potassium ions, and their consequences on the action potential along the three stages analyzed (Younger, Elder, and MCI Groups)
Functionality
Younger
Elder
MCI
Cellular response to Ca2+ ion
4.41
4.23
0
Ca2+ ion transport
15.06
4.19
2.72
Voltage-gated Ca2+ channels (VGCCs)
3.12
0
1.97
Ca2+ channel complex
3.58
1.46
1.71
Ca2+ & Calmodulin-dependent protein kinase complex
0
0
1.69
Na+ transmembrane transport
3.21
0
0
Voltage-gated Na+ channels (VGSCs)
1.97
0
0
K+ transmembrane transport
2.55
2.50
0
K+: H+ exchanger ATPase
1.58
1.80
0
Ranvier nodes
3.20
0
0
Action potential
9.43
4.12
3.48
Excitatory post-synaptic potential
4.41
3.00
1.96
Membrane depolarization
3.65
0
1.33
Membrane hyperpolarization
1.67
0
0
The significance is expressed as –log10 (FDR), where FDR is the false discovery rate. Note that a zero value denotes a non-significant functionality, as FDR = 1 (For details of the genes involved, see Tables S1–S3)
The author declares that he has no conflicts of interest.
Ethical approval
Not required.
Consent to participate
Not required.
Consent to publication
Not required.
Availability of data and materials
The original microarray data corresponding to the patients were gathered by Berchtold et al. [28, 29], and can be accessed under code GSE11882 in GEO database (https://www.ncbi.nlm.nih.gov/geo). The data generated in this study are available from Supplementary materials associated to the present article.
Open Exploration maintains a neutral stance on jurisdictional claims in published institutional affiliations and maps. All opinions expressed in this article are the personal views of the author(s) and do not represent the stance of the editorial team or the publisher.
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