Table Info

Table 6.

Sex-conditioned effects as derived from the pathway analyses

Sex-association	Functionality	FDR
Male (Younger Group)	Conservation of energy	6.5 × 10^–8
	Activation of AMPK by NMDAR	3.6 × 10^–3
	BDNF and NGF signaling	1.6 × 10^–3
	Pluripotency	1.6 × 10^–3
	p38 alpha-beta signaling	1.4 × 10^–5
	Dyrk1a in cell proliferation	1.4 × 10^–5
Female (Younger Group)	Post-synaptic events associated to NMDAR activation	1.7 × 10^–8
	Trafficking of GluR2-containing AMPAR	5.8 × 10^–6
	NOS1 activity	1.6 × 10^–3
	RAS activation by NMDAR	1.0 × 10^–4
	PKC-gamma and Ca²⁺ ion signaling	1.0 × 10^–4
	CREB1P-NMDAR activation	1.0 × 10^–4
	BDNF signaling	1.0 × 10^–3
	LTP	4.0 × 10^–5
Female (MCI Group)	p75NTR signaling	1.6 × 10^–5
	Cell death (mediated by NRAGE, NRIF, NADE)	1.4 × 10^–2
	NTRK2/TrkB through adapters FRS2 and FRS3	4.8 × 10^–4

FDR: false discovery rate; NMDAR: N-methyl-D-aspartate receptors; NTRK: neurotrophic tropomyosin-receptor kinases; BDNF: brain-derived neurotrophic factor; NGF: nerve growth factor; AMPAR: α-methyl-D-aspartate-3-hydroxy-5-methyl-4isoxazolepropionic acid receptors; LTP: long-term synaptic potentiation; MCI: mild cognitive impairment

Supplementary materials

The supplementary figures for this article are available at: https://www.explorationpub.com/uploads/Article/file/1001299_sup_1.pdf. The supplementary tables for this article are available at: https://www.explorationpub.com/uploads/Article/file/1001299_sup_2.xlsx.

Declarations

Acknowledgments

The author extends gratitude to Dr. Catalina A. Feledi for her valuable discussions and expert assistance in refining idiomatic expressions.

Author contributions

DVG: Conceptualization, Investigation, Visualization, Writing—original draft, Writing—review & editing.

Conflicts of interest

The author declares that he has no conflicts of interest.

Ethical approval

Not required.

Consent to participate

Not required.

Consent to publication

Not required.

Availability of data and materials

The original microarray data corresponding to the patients were gathered by Berchtold et al. [28, 29], and can be accessed under code GSE11882 in GEO database (https://www.ncbi.nlm.nih.gov/geo). The data generated in this study are available from Supplementary materials associated to the present article.

Funding

Not applicable.

Copyright

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