Table Info

Table 1.

Participant characteristics

		Time since last use
		≤ 6 month (not cease)	> 1 year (ceased)
AAs (N = 1192)	Number (% female)	701 (33.5%)	491 (40.5%)
	Age (Mean ± SD)	42.6 ± 8.5	45.6 ± 8.3
	OUD Symptom Counts (Mean ± SD)	7.8 ± 2.4	7.6 ± 2.5
	Number of families (number in families)	35 (76)	23 (47)
EAs (N = 2557)	Number (% female)	1714 (34.4%)	843 (40.6%)
	Age (Mean ± SD)	34.4 ± 10	40.5 ± 10.3
	OUD symptom Counts (Mean ± SD)	8.8 ± 1.9	8.4 ± 2.3
	Number of families (number in families)	114 (241)	31 (64)

SD: standard deviation

Supplementary materials

The supplementary materials for this article are available at:

https://www.explorationpub.com/uploads/Article/file/10013_sup_1.pdf

Declarations

Acknowledgments

We appreciate the work of recruitment and assessment by James Poling, PhD, at Yale University School of Medicine and the APT Foundation; by Roger Weiss, MD, at McLean Hospital; by Kathleen Brady, MD/PhD and Raymond Anton, MD, at the Medical University of South Carolina; and David Oslin, MD at the University of Pennsylvania. We thank John Farrell, PhD, Section of Biomedical Genetics, Boston University School of Medicine, who provided database management assistance.

Author contributions

JC designed, conducted the study and wrote the manuscript, R Sherva, KL, R Saitz, MK and LF supervised the study, HK and JG provided the access to the dataset. All authors contributed to manuscript revisions.

Conflicts of interest

Dr. Kranzler has been a consultant or advisory board member for Indivior and Lundbeck. He is also a member of the American Society of Clinical Psychopharmacology’s Alcohol Clinical Trials Initiative, which was supported for the last 3 years by AbbVie, Alkermes, Ethypharm, Indivior, Lilly, Lundbeck, Otsuka, Pfizer, Arbor, and Amygdala Neurosciences.

Ethical approval

This study was approved by the Institutional Review Boards of Boston University, Yale University and the University of Pennsylvania.

Consent to participate

Informed consent to participate in the study was obtained from all participants.

Consent to publication

Not applicable.

Availability of data and materials

The code used for this analysis can be found at https://github.com/wusixer/feature-selection-using-LASSO-SVM-and-Random-Forest and https://github.com/wusixer/feature_selection_in_neural_network.

Funding

This study was supported by National Institutes of Health grants RC2 DA028909, R01 DA12690, R01 DA12849, R01 DA18432, R01 AA11330, R01 AA017535, 2P50-AA012870, VA Connecticut Healthcare Center, Philadelphia VA MIRECCS, and National Center for Post Traumatic Stress Disorder. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Copyright

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