Association of VDR genotype frequencies in PCa and control participants
SNPs
Genotypes/Alleles
Cancer cases N (%)
Controls N (%)
p-value (χ2)
OR (95% CI)
rs1544410 BsmI
BB
16 (16%)
30 (30%)
0.927
1 (Reference)OR = 0.556; p = 0.446 (95% CI: 0.122–2.54)OR = 0.952; p = 0.947 (95% CI: 0.226–4.01)
Bb
38 (38%)
28 (28%)
bb
46 (46%)
42 (42%)
B
35%
44%
b
65%
56%
rs7975232 ApaI
AA
42 (42%)
41 (41%)
0.045*
1 (Reference)OR = 1.67; p = 0.3 (95% CI: 0.632–4.39)OR = 5.33; p = 0.024 (95% CI: 1.16–24.6)
Aa
44 (44%)
33 (33%)
aa
14 (14%)
26 (26%)
A
64%
57.5%
a
36%
42.5%
rs731236 TaqI
TT
41 (41%)
54 (54%)
0.029*
1 (Reference)OR = 1.98; p = 0.037 (95% CI: 1.05–8.47)OR = 4.63; p = 0.031 (95% CI: 1.09–19.7)
Tt
45 (45%)
27 (27%)
tt
14 (14%)
19 (19%)
T
63.5%
67.5%
t
36.5%
32.5%
SNPs: single nucleotide polymorphisms; OR: odds ratios; CI: confidence intervals; * statistically significant. Two OR are reported for each genotype. The first OR corresponds to the comparison between BB and Bb (AA and Aa) (TT and Tt) genotypes, and the second OR compares BB and bb (AA and aa) (TT and tt) genotypes. Each OR is accompanied by its p-value and 95% CI
Declarations
Acknowledgments
The authors would like to thank Hassan II University of Casablanca, Faculty of Sciences and Techniques—Mohammedia, the members of the team of Virology, Oncology and Biotechnologies, Laboratory of Virology, Oncology, Biosciences, Environment and New Energies. As well as the Laboratory of Research and Biosafety of Mohammed V Construction Teaching Hospital in Rabat, for their help during sample collection.
Author contributions
KN: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing—original draft. AL: Resources, Writing—review & editing. IT: Data curation, Investigation. KAT: Investigation, Methodology. MM and AA: Resources. KE: Data curation, Resources. MB: Supervision, Writing—review & editing. MME: Conceptualization, Data curation, Formal analysis, Investigation, Supervision, Validation, Writing—review & editing. All authors read and approved the submitted version.
Conflicts of interest
The authors declare that they have no conflicts of interest.
Ethical approval
The study protocol was approved by the Ethics Committee for Biomedical Research of the Faculty of Medicine and Pharmacy of Casablanca, Morocco (No. 3/2018/April 30, 2018).
Consent to participate
The informed consent to participate in the study was obtained from all participants.
Consent to publication
Not applicable.
Availability of data and materials
The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.
Open Exploration maintains a neutral stance on jurisdictional claims in published institutional affiliations and maps. All opinions expressed in this article are the personal views of the author(s) and do not represent the stance of the editorial team or the publisher.
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