Table Info

Table 1.

Demographic information on opioid-exposed individuals contributing to analysis of the trait time to opioid use disorder

Cohort	AA				EA
Cohort	Age μ (SD)	Sex N (%) male	OD cases (N, mean years to dependence)	OD controls (N, mean years to censoring)	Age μ (SD)	Sex N (%) male	OD cases (N, mean years to dependence)	OD controls (N, mean years to censoring)
Yale-Penn	42.2 (9.0)	1,500 (66)	1,307 (3.6)	974 (14.9)	36.7 (10.8)	1,977 (64)	2,340 (3.8)	768 (13.9)
COGA	56.6 (13.7)	325 (65)	144 (4.3)	354 (13.8)	49.7 (14.6)	1,047 (64)	334 (3.4)	1,305 (13.6)
CATS	NA	NA	NA	NA	36.5 (8.6)	778 (59.6)	1217 (3.8)	88 (10.5)

Supplementary materials

The supplementary materials for this article are available at:

https://www.explorationpub.com/uploads/Article/file/100132_sup_1.pdf

Declarations

Author contributions

JG, LAF, HRK, HJE, EN, NGM, and LD contributed conception and design of the study; CZ, EJ, and LW, and RS performed the statistical analysis; RS wrote the first draft of the manuscript; all authors contributed to manuscript revision, read and approved the submitted version.

Conflicts of interest

Dr. Kranzler is a member of an advisory board for Dicerna Pharmaceuticals and a member of the American Society of Clinical Psychopharmacology’s Alcohol Clinical Trials Initiative (ACTIVE Group), which over the past three years was supported by Alkermes, Amygdala Neurosciences, Arbor Pharmaceuticals, Ethypharm, Indivior, Lundbeck, Mitsubishi, and Otsuka. Drs. Kranzler and Gelernter are named as inventors on PCT patent application #15/878,640 entitled: “Genotype-guided dosing of opioid agonists”, filed January 24, 2018. In the past three years, Dr. Degenhardt has received untied educational grant funding from Indivior and Seqirus. No other authors reported potential conflicts of interest.

Ethical approval

This study was approved by the Institutional Review Boards of Boston University, Yale University and the University of Pennsylvania.

Consent to participate

Informed consent to participate in the study was obtained from all participants.

Consent to publication

Not applicable.

Availability of data and materials

Summary statistics for GWAS analyses will be provided by the corresponding author upon request.

Funding

This study was supported by National Institutes of Health grants RC2 DA028909, R01 DA12690, R01 DA12849, R01 DA18432, R01 AA11330, R01 AA017535, 2P50-AA012870, VA Connecticut Healthcare Center, Philadelphia VA MIRECCS, and National Center for Post Traumatic Stress Disorder. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Copyright

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