Table Info

Table 2.

Examples of clinically approved nanomedicine

Year of approval	Name	Nanotechnology platform	Therapeutic agent	Indication	Refs
1995 (FDA) 1996 (EMA)	Doxil/Caelyx	Liposome (PEGylated)	Doxorubicin	HIV-associated Kaposi sarcoma, ovarian cancer, metastatic breast cancer, multiple myeloma	[9]
1996 (FDA)	DaunoXome	Liposome (non-PEGylated	Daunorubicin	HIV-associated Kaposi sarcoma	[10]
2002 (FDA)	Eligard	poly(D, L-Lactide-co-glycolide) (PLGH)	Leuprorelin acetate	Prostate cancer	[11]
2005 (FDA) 2008 (EMA)	Abraxane	Nanoparticle albumin bound	Paclitaxel	Advanced non-small-cell lung cancer, metastatic breast cancer, metastatic pancreatic cancer	[12]
2006 (FDA)	Oncaspar	polyethyleneglycol (PEG) protein conjugate	L-asparaginase	Leukemia	[13]
2009 (EMA)	MEPACT	Liposome (non-PEGylated)	Mifamurtide	Osteosarcoma	[14]
2015 (FDA)	MM-398/Onivyde	Liposome (PEGylated)	Irinotecan	Metastatic pancreatic cancer	[15]
2017 (FDA)	VYXEOS	Liposome	Daunorubicin and cytarabine	Acute myeloid leukemia	[16]
2019 (FDA)	Polivy (polatuzumab vedotin-piiq)	Antibody-drug conjugate	Monomethyl auristatin E	Relapsed diffuse large B-cell lymphoma	[17]

FDA: Food and Drug Administration; EMA: European Medicines Agency

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Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

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Availability of data and materials

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Funding

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Copyright

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