Table Info

Table 5.

Sleep fragmentation and DTI

Diffusion Tensor Measure	Model 1 e-LFC (P)	Model 2 e-LFC (P)	Model 3 e-LFC (P)	Model 1 e-LFC_BB (P)	Model 2 e-LFC_BB (P)	Model 3 e-LFC_BB (P)	Model 1 e-LFC_NB (P)	Model 2 e-LFC_BB (P)	Model 3 e-LFC_NB (P)
FA	0.91	0.04	0.05	0.89	0.15	0.16	0.97	0.03	0.03
MD	1.00	0.06	0.0046	0.99	0.22	0.19	0.97	0.02	0.01
PSMD	0.45	0.45	0.37	0.84	0.82	0.69	0.38	0.11	0.12

Moderating effects of gender

Diffusion Tensor Measure	Model 1 e-LFC (P)	Model 2 e-LFC (P)	Model 3 e-LFC (P)	Model 1 e-LFC_BB (P)	Model 2 e-LFC_BB (P)	Model 3 e-LFC_BB (P)	Model 1 e-LFC_NB (P)	Model 2 e-LFC_BB (P)	Model 3 e-LFC_NB (P)

FA	-	-	0.006	-	-	0.15	-	-	< 0.001
MD	-	-	0.06	-	-	0.30	-	-	0.006
PSMD	-	-	0.005	-	-	0.007	-	-	0.15

Fully adjusted model shown for gender; statistical significance is shown; -: only full model computed

Declarations

Author contributions

RJT conceptualized the study design and analysis and drafted the manuscript; PM provided technical MRI details, and critically reviewed the manuscript; HK performed statistical analysis and reviewed the manuscript, EJH interpreted raw data and reviewed the manuscript, CSD was responsible for the brain imaging and reviewed the manuscript, CK and TFAA organized, managed, and analyzed data and reviewed the manuscript, RA conceptualized the study design, organized the data collection, and reviewed the manuscript. All authors contributed to manuscript revision, read, and approved the submitted version.

Conflicts of interest

Dr. Thomas reports patent and licenses with royalties from MyCardio, LLC, for the ECG-spectrogram, unlicensed patent for a CO2 regulating device for treatment of central and complex sleep apnea, license with royalties’ from DeVibiss-Drive for an auto-CPAP algorithm, and a general sleep medicine consultant for Guidepoint Global and GLG Councils. Dr. Au has no conflicts of interest but is on the Scientific Advisory Board of Signant Health and is a scientific consultant to Biogen. The other authors declare that they have no conflicts of interest.

Ethical approval

The research study was approved by the Institutional Review Boards of the Beth Israel Deaconess Medical Center (2103P000121) and Boston University (H-32375).

Consent to participate

The informed consent to participate in the study was obtained from all participants.

Consent to publication

Not applicable.

Availability of data and materials

The data supporting this report can be obtained through standard processes from the Framingham Heart Study Service Center. https://framinghamheartstudy.org/fhs-for-researchers/fhs-service-center/

Funding

Support was provided by the Beth Israel Deaconess Medical center Chief Academic Officer’s Innovation Fund, the Framingham Heart Study’s National Heart, Lung, and Blood Institute contract (N01-HC-25195; HHSN268201500001I), by grants (R01-AG016495, R01-AG008122, R01-AG033040, R01-AG054156; R56 AG062109) from the National Institute on Aging, and by grant (R01-NS017950) from the National Institute of Neurological Disorders and Stroke and a grant from Pfizer. The study sponsors had no role in the study design; in the collection, analysis, and interpretation of the data; in the writing of the report; and in the decision to submit the paper for publication.

Copyright

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