Central effects of Ang-(1-7)/MasR

Ang-(1-7) induced effectReferences
Decrease in blood pressure mediated by NOFeng et al., 2010 [105]
Decrease in NE releaseGironacci et al., 2004 [99]
Decrease in NE synthesisLopez Verrilli et al., 2009[78]
NE transporter upregulationLopez Verrilli et al., 2012[79]
AngiogenesisGoldstein et al., 2016 [106]
Decrease in BBB permeabilityWu et al., 2015 [107]
Protection of neurons and oligodendrocytesRabie et al., 2018 [108]
Decrease in infarct sizeMecca et al., 2011 [109]
Improvement in neurological deficits induced by strokeJiang et al., 2013 [28]
Promotion of cell survival and healthy synapse formationCosta-Besada et al., 2018 [66]
Decrease in superoxide production in nucleus and mitochondria of neurons of the substancia nigraCosta-Besada et al., 2018 [66]
Increase in vasopressin releaseQadri et al., 1998 [110]
Increase of BDNF productionRabie et al., 2018 [108]
Increased neuronal survival due to reduction of oxidative stress mediated by PKAMo et al., 2019 [111]
Reduction in microglial activation and astrogliosisJanatpour et al., 2019 [112]
Reduction in inflammation by inhibition of the MAPKs pathwayMoore et al., 2013 [113]
Increase of the M2 microglial anti-inflammatory phenotype in microgliaLiu et al, 2016 [114]
NOS upregulationCerrato et al., 2012 [82]
Reduction in oxidative stressJiang et al., 2013 [28]
Costa-Besada et al., 2018 [66]
Stimulation of prostaglandin release in endothelial cellsJaiswal et al., 1992 [115]
Stimulation of neuronal activity in hypothalamus and medullaFontes et al.,1994 [116]
Increased sensitivity to baroreflexCampagnole-Santos et al., 1992 [117]
Increased IL-10 and decreased TNFα and IL1βSriramula et al., 2011[86]
Increase of arachidonic acid releaseCerniello et al., 2020 [36]
MAPKs and PKB/Akt activationRabie et al., 2018 [108]

BDNF: brain derived neurotrophic factor; IL: interleukin; MAPK: mitogen-activated protein kinase; MCP-1: Monocyte chemoattractant protein-1; NOS: nitric oxide synthase; PKB: protein kinase B; TNFα: Tumor necrosis factor alpha