Table Info

Table 1.

Sexually dimorphic hepatic genes associated with NAFLD

Gene	Function (s)	Model (s) Used	Female	Male	Effect (s)
JNK	Transcription factor; regulate fatty acid oxidation; improve insulin sensitivity	SHROB Rats	↑↑	↑	Less severe steatosis in females
AMPK	Transcription factor; regulate fatty acid oxidation; improve insulin sensitivity	SHROB Rats	↑↑	↑	Less severe steatosis in females
CD36	Receptor; promotes fatty acid uptake into muscle and adipose tissues; fatty acid transport, β-oxidation	SHROB Rats; FXR-deficient mice; C57BL6/J HFD Mice	↑↑	↑	Less severe steatosis in females
PPARγ	Transcription factor; activates SREBP-1c, a master transcription factor that promotes de novo lipid synthesis (DNL)	SHROB Rats	↑	↑↑	More severe steatosis and inflammation in males
PNPLA3	Enzyme; involved in the accumulation of lipid droplets; esterification	SHROB Rats; C57BL6/J HFD Mice	↑	↑↑	More severe steatosis and inflammation in males
AQP7	The main channel in facilitating the release of lipolytic glycerol from adipocytes	C57BL/6 HFD mice, streptozotocin-induced DM rats	↑↑	↑	Increase plasma glycerol levels in both sexes
AQP9	The principal facilitative pathway in liver uptake of glycerol	C57BL/6 HFD mice, streptozotocin-induced DM rats	↓↓ (Expression and glycerol permeability)	↓	Less severe steatosis and hyperglycemia in females

SHROB: obese spontaneously hypertensive; ↑ increased; ↑↑ highly increased; ↓ decreased; ↓↓ highly decreased

Declarations

Author contributions

NCS; PJG; CT and NR contributed conception and design of the review and in the writing of the different sections of the review. All authors contributed to manuscript revision, read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

NCS is funded by the Department of Science and Technology-Philippine Council for Health Research and Development (DOST-PCHRD), Philippines; PJG is supported by Post-doctoral Fellowships 2020 from Fondazione Umberto Veronesi, Italy; NR is funded by Fondazione Cassa di Risparmio di Trieste (CRTrieste) and by Fondazione Italiana Fegato ONLUS.

Copyright

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