Myofibrillar ATPase activities, protein content and mRNA levels in control and MI animals with or without ENP and LOS for 5 weeks starting at 3 weeks after induction of MI
Parameters
Control
MI
MI + ENP
MI + LOS
A. MF activities (μmol Pi/mg per h)
Ca2+-stimulated ATPase activity
10.8 ± 0.4
7.1 ± 0.4*
8.3 ± 0.65
7.9 ± 0.52
Mg2+-ATPase activity
3.6 ± 0.4
3.8 ± 0.45
3.2 ± 0.3
3.2 ± 0.3
B. Myosin heavy chain content (% of total)
Total MHC
100
96.2 ± 4.9
100.0 ± 4.6
96.0 ± 9.8
α-MHC
93.5 ± 2.4
71.0 ± 1.8*
83.6 ± 1.3†
85.4 ± 1.6†
β-MHC
6.5 ± 0.3
29.0 ± 1.5*
17.6 ± 1.2†
13.8 ± 0.4†
C. Myosin heavy chain mRNA levels (Relative intensity)
α-MHC
92.25 ± 0.25
71.25 ± 1.25*
81.90 ± 1.9†
82.75 ± 2.5†
β-MHC
7.50 ± 0.25
30.00 ± 1.25*
19.75 ± 1.75†
15.62 ± 0.12†
Values are mean ± SE of 7 animals in each group. MLC: myosin light chain. Data are based on the analysis of the information in Figures 1, 2 and 3 in our paper Wang et al. Biochim Biophys Acta. 2004;1690:177–84 [119]. *P < 0.05 compared with control; †P < 0.05 compared with MI group
Declarations
Acknowledgments
The infrastructure support for this project was provided by the St. Boniface Hospital Research Foundation, Winnipeg, Canada. Thanks are also due to Ms. Andrea Opsima for typing this manuscript.
Author contributions
SKB searched the literature, analyzed the data and wrote the first draft; AKS analyzed the data and wrote the manuscript; NSD conceived, designed and edited the article. All authors have read and agreed to the published version of the manuscript.
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