Exploration of Targeted Anti-tumor Therapy

Table 1. ADCs approved by FDA sorted based on the year of their first approval

ADC	Target	Disease with FDA approval	Approval year
Gemtuzumab ozogamicin	CD33	Acute myeloid leukemia	2000^*, 2017
Brentuximab vedotin	CD30	ALCL, CTCL, HL, MF, PTCL	2011^*, 2018
Trastuzumab emtansine	HER2	Breast cancer	2013
Inotuzumab ozogamicin	CD22	Lymphoblastic leukemia-lymphoma	2017
Moxetumomab pasudotox	CD22	HCL	2018
Polatuzumab vedotin	CD79B	DLBCL	2019
Enfortumab vedotin	Nectin-4	Urogenital cancer	2019
Trastuzumab deruxtecan	HER2	Breast cancer, gastric cancer	2019
Sacituzumab govitecan	Trop-2	Breast cancer, urogenital cancer	2020
Belantamab mafodotin	BCMA	Multiple myeloma	2020
Loncastuximab tesirine	CD19	DLBCL	2021

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approved as monotherapy; ALCL: anaplastic large cell lymphoma; BCMA: B cell maturation antigen; CTCL: cutaneous T cell lymphoma; DLBCL: diffuse large B cell lymphoma; HCL: hairy cell leukemia; HER2: human epidermal growth factor receptor 2; HL: Hodgkin’s lymphoma; MF: mycosis fungoides; PTCL: peripheral T cell lymphoma

Declarations

Author contributions

MB: data curation and writing – original draft; NL: data curation and writing – review & editing; CT: writing – review & editing; FS: writing – review & editing; PB: writing – review & editing; FB: data curation and writing – review & editing.

Conflicts of interest

Francesco Bertoni: institutional research funds from Acerta, ADC Therapeutics, Bayer AG, Cellestia, CTI Life Sciences, EMD Serono, Helsinn, ImmunoGen, Menarini Ricerche, NEOMED Therapeutics 1, Nordic Nanovector ASA, Oncology Therapeutic Development, Oncternal Therapeutics, PIQUR Therapeutics AG; consultancy fee from Helsinn, Menarini; expert statements provided to HTG; travel grants from Amgen, Astra Zeneca, Jazz Pharmaceuticals, PIQUR Therapeutics AG. The other authors have nothing to disclose.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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