Table Info

Table 6.

Selection of significantly differentially expressed genes that correspond to the characteristics of tumors

Genes	Function in tumor cells	Log₂ fold change	P adjusted	Reference
WNT5a	Oncogen and tumor suppressor, associated with invasion, proliferation, and EMT	5.711	0.001	[82]
MMP3	Associated with metastasis	5.314	0.002	[83]
SOX2	Associated with tumor growth and metastasis	5.232	0.005	[84]
TMPRSS4	Associated with tumor proliferation and metastasis	5.153	0.002	[85]
FOXE1	Associated with tumor growth	4.949	0.020	[86]
FOXQ1	Associated with metastasis	4.882	0.005	[87]
TNC	Associated with metastasis and EMT	4.653	0.002	[88]
TBX2	Associated with tumor proliferation	4.508	0.007	[89]
CRYAB	Antiapoptotic factor	4.474	0.007	[90]
MMP2	Associated with metastasis	4.249	0.002	[83]
PTHLH	Associated with tumor growth	4.244	0.041	[91]
EMP2	Associated with angiogenesis	4.211	0.001	[92]
CCN1	Associated with tumor growth	4.203	0.006	[93]
SPP1	Associated with tumor growth and metastasis	4.196	0.018	[94]
GPNMB	Associated with metastasis	4.064	0.003	[95]
ANO1	Associated with metastasis	4.028	0.014	[96]
MMP12	Associated with metastasis	3.952	0.083	[83]
YAP1	Associated with tumor growth	3.870	0.001	[97]
MMP13	Associated with metastasis	3.832	0.077	[83]
SNAI2	Associated with EMT and metastasis	3.813	0.012	[98]

EMT: epithelial mesenchymal transition; MMP3: matrix metalloproteinase 3; SOX2: SRY-box transcription factor 2; TMPRSS4: transmembrane serine protease 4; FOXE1: forkhead box E1; TNC: tenascin C; TBX2: T-box 2; CRYAB: crystallin alpha B; PTHLH: parathyroid hormone like hormone; EMP2: epithelial membrane protein 2; CCN1: cellular communication network factor 1; SPP1: secreted phosphoprotein 1; GPNMB: glycoprotein nmb; ANO1: anoctamine 1; YAP1: Yes associated protein 1; SNAI2: snail family transcriptional repressor 2

Supplementary materials

The supplementary material for this article is available at: https://www.explorationpub.com/uploads/Article/file/1002143_sup_1.xlsx.

Declarations

Acknowledgments

Thanks are due to Ivonne Görlich, Katja Hasch, Gabriela Cudek and Monika Jerg for excellent technical assistance.

Author contributions

HAK and CB: Conceptualization, Methodology, Data Curation, Supervision, Project administration. HAK, MG, JMK and JE: Software. HAK, JMK, MG, LTH, AW, JE and CB: Validation, Investigation. JMK, MG, LTH, JE and AW: Formal analysis. HAK, TKH and CB: Resources. LTH and CB: Writing—original draft. HAK, JMK, MG, AW, JE, BW, SL and TKH: Writing—review and editing. JMK, JE and LTH: Visualization. All authors read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

The study was approved by the local ethics committee of the Ulm University [90/15] and complies with the Declaration of Helsinki.

Consent to participate

Informed consent to participate in the study was obtained from all participants.

Consent to publication

Not applicable.

Availability of data and materials

RNA-seq data are available from Gene Expression Omnibus (GEO, https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE156554) under Record ID GSE156554.

Funding

Not applicable.

Copyright

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