Table Info

Table 3.

Effects of free ISG15 that may be relevant in a cancer context

Effect	Description of free ISG15-associated effects	Reference
Regulation of IFN signaling	In humans, JAK1-IFNAR2 interaction is disrupted by USP18, affecting IFN-α/β signaling Free ISG15 interacts with USP18, inhibiting its degradation by SKP2	[67]
Protein complex disassembly	Intracellular free ISG15 interrupts the USP18-SKP2 interaction promoting the stability of USP18	[68]
Regulation of E3-ubiquitin ligase activity	Free ISG15 binds to the E3-ubiquitin ligase NEDD4 to interrupt its interaction with the E2 biquitin-conjugating enzyme, decreasing ubiquitination	[69]
Participation in selective autophagy	LRRC25 inhibits the IFN-signaling by promoting lysosomal degradation of ISG15-associated RIG-1	[70]

JAK1-IFNAR2: janus kinase 1-IFN α and β receptor subunit 2; SKP2: S-phase kinase-associated protein 2; NEDD4: NEDD4 E3 ubiquitin protein ligase (also known as NEDD4-1 or RPF1, neural precursor cell expressed, developmentally down-regulated 4); LRRC25: leucine-rich repeat containing 25; RIG-1: RNA sensor RIG-1

Declarations

Acknowledgments

JZC thanks the Subprogram for the Incorporation of Young Career Academics (SIJA) from Dirección General de Asuntos del Personal Académico (DGAPA)-UNAM.

Author contributions

ACTC: Conceptualization, Investigation, Writing—original draft, Writing—review & editing. JZC: Investigation, Validation, Writing—review & editing. Two authors read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

This research was supported by the School of Science and Technology [CCyT-2022-08 to ACTC] from the Autonomous University of Mexico City (UACM). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Copyright

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