Quantitative results of the analyzed biomarkers in the study population

BiomarkerPrimary tumorMetastasis
MET (% positive cells)Mean44.672.4
Median5090
Range0–1000–100
MET (number of cases)Negative21
1 (+)123
2 (++)77
3 (+++)414
mTOR (% positive cells)Mean28.126.4
Median3010
Range0–800–90
mTOR (number of cases)Negative56
1 (+)212
2 (++)62
3 (+++)125
4EBP1 (% positive cells)Mean42.882.8
Median30100
Range0–1005–100
4EBP1 (number of cases)Negative30
1 (+)82
2 (++)65
3 (+++)818
S6RP (% positive cells)Mean5.832
Median020
Range0–700–100
S6RP (number of cases)Negative195
1 (+)38
2 (++)35
3 (+++)06