The differential effects of melatonin, TrkB and GR on immune cell pro-inflammatory activation, as well as in tumor cell survival/proliferation
| Cell type | Melatonin | TrkB | GR | References | |
|---|---|---|---|---|---|
| Immune cell | Macrophage | – | – | – | [84, 102, 103] |
| Microglia | – | + | – | [23, 104, 105] | |
| NK cell | + | – | – | [106–108] | |
| CD8+ T cell | + | + | – | [56, 109, 110] | |
| DC | – | + | – | [111–113] | |
| Treg | + | ? | + | [91, 114] | |
| Mast cell | – | ? | – | [58, 80] | |
| Neutrophil | – | –/? | – | [52, 85, 115] | |
| Astrocyte | – | –/+ | + | [116–118] | |
| MDSC | – | N/A | + | [59, 119] | |
| Tumor cell | – | + | + | [17, 18, 93] | |
+: stimulatory; –: inhibitory; N/A: no data available; MDSC: myeloid-derived suppressor cell; ?: requires data. –/? is meant to represent some data suggestive of “inhibitory” but requires more data
