The characteristics of articles included in a systematic review of the effect of COVID-19 on HCC treatment

ReferencePlace (country)Sample sizeType of studyReview period or comparison dateQuality assessment
Aghemo et al. [28]Italy194 Italian AISF membersProspective web-based surveyFrom April 8, 2020 to May 3, 2020Fair
Buonaguro et al. [34]Naples and ItalyNANAMarch 2020 compared to 2019Poor
El Kassas et al. [42]EgyptNANALetter without dataPoor
Kounis et al. [35]France32 Patients with HCCNABetween April 15 and May 15, 2020 vs. the same time in 2019Poor
Iavarone et al. [29]Italy

2019: 117

2020: 77

NAFrom February to March 20, 2020 vs. the same time in 2019Poor
Mario et al. [39]Italy

2019: 12

2020: 7

Single-center studyMarch 9 to April 30, 2019 vs. the same time in 2020Fair
Martinez et al. [30]Latin American229 CentresGlobal surveyFrom May 6 to May 30, 2020Fair
Toyoda et al. [31]US, Japan, and Singapore3 Medical centersSurveyMarch 1 to March 14, 2018, 2019, and 2020 and March 15 to May 1, 2018, 2019, and 2020Fair
Amaddeo et al. [19]France

6 Referral centers

(670):

2020: 293

2019: 377

Retrospectiveand cross-sectional studyFirst 6 weeks of the COVID-19 pandemic (exposed) vs. the same period in 2019 (non-exposed)Good
Bargellini et al. [40]Italy

2019: 487

2020: 353

RetrospectiveFrom the lockdown started until the phase of exiting the lockdown vs. the same time in 2019Good
Crespo et al. [32]Spain81 HospitalsMulticenter nationwide surveyBetween March 30 and April 3, 2020Good
Gandhi et al. [18]14 Asia-Pacific countries2,789 vs. 2,045 patients with new HCC diagnosesSurveyFebruary to May 2019 (pre-pandemic) vs. the same period in 2020 (pandemic period)Good
Hartl et al. [38]Austria279 Cohort 1 and 138 cohort 2TelesurveyDecember 2019 to February 2020 and March to May 2020Good
Jin et al. [41]China

2020: 71, study group

2019: 83, control group

RetrospectiveFrom January 2020 to March 2020 compared with the same period in 2019 Good
Iavarone et al. [25] Italy

2019: 555

2020: 579

Retrospective study2020 vs. 2019Good
Muñoz-Martínez et al. [26]76 Countries76 Centers around the worldInternational surveyFrom May 2020 to June 2020Fair
Pomej et al. [22]Austria

104 Males

22 Females

RetrospectivelyBetween December 30, 2019 and June 30, 2020Good
Ponziani et al. [37] Italy55 Different units present in 43 Italian hospitalsOnline surveyJanuary 15 to March 15, 2021 (second/third pandemic waves) vs. the same time in 2020Good
Tan et al. [36]Hong Kong (China) and Singapore111Modelling studyJune 1, 2019 to May 30, 2020Good
Zhao et al. [33]China42 Class-A tertiary hospital, 664 doctorsNationwide online questionnaire surveyIn COVID-19 periodGood

AISF: Association for the Study of the Liver