Comparison of the physical properties of CLIPTAC precursor molecules (71–73) to published BET degraders (1–3)
Compound
MW
cLogP
TPSA
71
572
1.2
173
72
609
5.9
111
73
586
6.5
130
MZ1 (1)
1003
4.9
211
ARV-825 (2)
924
4.8
205
dBET1 (3)
785
2.5
194
Declarations
Author contributions
All authors contributed to the conception and organisation of this review. RT prepared the first draft of the manuscript, and all authors contributed to the writing and development of additional sections. All authors contributed to manuscript revision and approved the submitted version.
Conflicts of interest
The authors declare that they have no conflicts of interest.
Ethical approval
Not applicable.
Consent to participate
Not applicable.
Consent to publication
Not applicable.
Availability of data and materials
Not applicable.
Funding
This work was supported by AstraZeneca with a CASE award, and the EPSRC with a CASE Conversion grant (EP/R513325/1). AstraZeneca approved the final submitted version of the manuscript. The industrial supervisor/author (CF), together with the other authors, contributed to the design, writing, proof-reading and submission of this review.
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