Table Info

Table 1.

Targets of succinylation in the mitochondria

Protein	Sites	Pathway	Model	Reference
Carbamoyl phosphate synthase 1 (CPS1)	-	Urea cycle	Mouse liver	[45]
Ornithine transcarboxylase (OTC)	K88	Urea cycle	Mouse liver	[45]
SDH subunit A (SDHA)	K182	TCA cycle	SIRT5 KO mouse adipose-derived mesenchymal stem cells (ADMSCs)	[57]
2-Oxoglutarate dehydrogenase E1 (OGDH)	K276
Malate dehydrogenase 2 (MDH2)	K239, K307, K335
Citrate synthase (CS)	-		SIRT5 KO mouse brain after subarachnoid haemorrhage (SAH)	[54]
ATP synthase	-		SIRT5 KO mouse brain after subarachnoid haemorrhage (SAH)	[54]
Uncoupling protein-1 (UCP-1)	K56, K73, K151, K67	Thermogenesis Glutamine metabolism	SIRT5 KO mouse BAT	[58]
Glutamate dehydrogenase 1 (GLUD1)	K90, K480
SDHA	K179, K485
SDHB	K169
Mitochondrial trifunctional enzyme subunit alpha (ECHA)	K351	Fatty acid oxidation	SIRT5 KO mouse heart	[50]
SDHA	K179 K335	Mitochondrial respiration	SIRT5 KO mouse heart after TAC	[59]
Hydroxyaryl-CoA dehydrogenase subunit A (HDHA)	K351	Mitochondrial respiration	SIRT5 KO mouse heart after TAC	[59]
Very long-chain acyl-CoA dehydrogenase (VLCAD)	K299, K482, K492, K507	Fatty acid oxidation	VLCAD KO and SIRT5 KO mouse	[60]
SDHA	K547	Mitochondrial respiration	Human renal cell carcinoma	[61]
IDH2	-	Reduced form of NAD phosphate (NADPH) metabolism	SIRT5 KO mouse breast cancer cells	[62]
Glutaminase (GLS)	K311	Glutamine metabolism	Human pancreatic cancer cells	[63]
Glutaminase (GLS)	K164	Glutamine metabolism	Human breast and lung cancer cells	[64]
Serine hydroxymethyltransferase-2 (SHMT2)	K280	Anti-oxidant mechanism	Human colorectal carcinoma	[65]
Mitochondrial antiviral signalling protein (MAVS)	K7	Interferon response	SIRT5 KO mouse MEFs Human Embryonic Kidney 293 (HEK293T)	[66]

-: no data

Declarations

Author contributions

KFK: Conceptualisation, Writing—original draft, Writing—review & editing, Supervision. DY and YG: Writing—original draft. All authors read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

YG was funded by a State Scholarship from the Chinese Scholarship Council [202208080293]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Copyright

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