Table Info

Table 2.

Targets of cytoplasmic succinylation

Protein	Sites	Pathway	Model	Reference
SOD1	K123	Anti-oxidant mechanism	Lung tumour cells HEK293T	[83]
ACOX1	K89, K437, K488, K500, K537	Fatty acid oxidation	SIRT5 KO mouse Human hepatocellular carcinoma (HCC) cancer samples	[84]
PKM2	K433	Glycolysis	Human cancer cells Colon cancer specimens	[85]
	K311	PKM2-HIF-1α-IL-1β	Bone marrow-derived macrophages (BMDMs)	[86]
	K498	Anti-oxidant mechanism	Human lung carcinoma cells	[87]
ENO1	K80, K81 K355	Cell proliferation	Breast cancer cells	[28]
PGAM1	K99	Glycolysis	Human pancreatic cancer cells	[27, 88]
LDHA	K118		Prostate cancer cells	[89]
LDHA	K222		Human gastric cancer (GC) samples	[90]
TAGLN2	K40	Cytoskeletal rearrangement	Human glioblastoma samples and cells	[91]
FBN1	K672	Transforming growth factor β1 (TGFβ1)-PI3K/Akt	Huma primary gastric adenocarcinoma samples	[92]
S100A10	K47	Tumour migration and invasion	Human GC tissues	[93]

Declarations

Author contributions

KFK: Conceptualisation, Writing—original draft, Writing—review & editing, Supervision. DY and YG: Writing—original draft. All authors read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

YG was funded by a State Scholarship from the Chinese Scholarship Council [202208080293]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Copyright

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