Table Info

Table 1.

Summary of evidence for most promising methylation biomarkers for diagnosis of CRC in tissue (sensitivity > 75%)

Biomarker gene(s)	Sensitivity (%)	Specificity (%)	Reference
AKR1B1, SEPT9	98	99	[23]
APC, MGMT, RASSF2A, WIF1	87	92	[22]
APC, p16^INK4a, MGMT, RARB2	77	100	[24]
BMP3	84	95	[25]
CDH1	87	74	[26]
CMTM3, MDFI, SSTR2	81	91	[27]
CNRIP1, FBN1, INA, MAL, SNCA, SPG20	94	98	[21]
GDNF, SNAP91, NDRG4	86	96	[28]
EFHD1	79	78	[29]
ITGA4	89	88	[30]
NDRG4	81–92	92–95	[25, 31]
MGMT, RASSF1A, SEPT9	97	74	[11]
SEPT9	78–97	96–97	[32, 33]
SFRP1	93	100	[34]
SFRP2	83–91	100	[35, 36]
SPG20	94	99	[21]
TFPI2	99	94	[10]
VIM	86	95	[37]

AKR1B1: aldo-keto reductase family 1 member B; SEPT9: septin 9; RARB2: retinoic acid receptor beta 2; BMP3: bone morphogenetic protein 3; CDH1: cadherin 1; CMTM3: CKLF like MARVEL transmembrane domain containing 3; MDFI: myoD family inhibitor; SSTR2: somatostatin receptor 2; GDNF: glial cell derived neurotrophic factor; SNAP91: synaptosome associated protein 91; NDRG4: NDRG family member 4; EFHD1: EF-hand domain family member D1; ITGA4: integrin subunit alpha 4; VIM: vimentin

Declarations

Author contributions

JY: Data curation, Writing—original draft. JZ and WD: Conceptualization, Investigation, Writing—review & editing. All authors revised the manuscript and approved the final version of it.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

The work was supported by the National Natural Science Foundation of China [81974313]; Postdoctoral Science Foundation of China [2019M651930]; the Natural Science Foundation of Jiangsu Commission of Health [M2020065]; the Science and Technology Program of Nantong [JC22022040]; Nantong Commission of Health Research Fund Project [MA2021004]; Jiangsu Provincial Research Hospital [YJXYY202204]; and Jiangsu Provincial Medical Key Discipline [ZDXK202240]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Copyright

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