Summary of β-particle radioimmunotherapies evaluated in clinical trials of NHL
Radionucleotide-labeled antibody | Target | USA Food and Drug Administration (FDA) approval | Reference |
---|---|---|---|
90Y-ibritumomab-tiuxetan | CD20 | Yes (February 2002) | [10–20] |
131I-tositumomab | CD20 | Yes (June 2003) | [21–24] |
90Y-epratuzumab tetraxetan | CD22 | No (Only phase I/II study) | [25] |
177Lu-lilotomab satetraxetan | CD37 | No (Only phase I/II study) | [26–30] |
We thank Kumiko Fukushima for secretarial assistance (Kumamoto University).
HG: Conceptualization, Writing—original draft, Writing—review & editing, Supervision. SO: Conceptualization, Writing—review & editing, Supervision. YS: Writing—review & editing. All authors read and approved the submitted version.
The authors declare that they have no conflicts of interest.
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© The Author(s) 2024.