Table Info

Table 3.

Summary of preclinical investigations in α-particle RIT of NHL

Radionucleotide-labeled antibody	Lymphoma	Comparison with ⁹⁰Y-tiuxetan-ibritumomab	Reference
²²⁷Th-DOTA-p-benzyl-rituximab	Burkitt lymphoma (Raji)	Yes	[44]
²¹²Pb-TCMC-rituximab	Mouse lymphoma (EL4-hCD20-Luc)	No	[45]
²¹²Pb-TCMC-NNV003 (anti-CD37)	Burkitt lymphoma (Daudi), chronic lymphocytic leukemia (MEC-2)	No	[46]
²¹³Bi-(R)-2-amino-3-(4-isothiocyanatophenyl)propyl)-trans-(S,S)-cyclohexane-1,2-diamine-pentaacetic acid (SCN-CHX-A”-DTPA)-rituximab	Burkitt lymphoma (Raji)	Yes	[47]
²¹¹At-1F5-B10 (anti-CD20)	Burkitt lymphoma (Ramos), mantle cell lymphoma (Granta-519)	No	[48]
²²⁵Ac-DOTA-ofatumumab	Burkitt lymphoma (Raji)	No	[49]

Declarations

Acknowledgments

We thank Kumiko Fukushima for secretarial assistance (Kumamoto University).

Author contributions

HG: Conceptualization, Writing—original draft, Writing—review & editing, Supervision. SO: Conceptualization, Writing—review & editing, Supervision. YS: Writing—review & editing. All authors read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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