Table Info

Table 2.

A comprehensive list of ongoing oncology clinical trials involving IL-15 in haematological cancers

Clinical trial ID	Phase	Number of patients	Cancer type	Treatment	Status	Estimated study completion date
NCT05110742	Phase 1/2	48	Various haematological malignancies	CAR.5/IL-15-transduced CB-NK cells plus cyclophosphamide plus fludarabine	Not yet recruiting	December 2027
NCT04814004	Phase 1	20	B-cell malignancies	hCD19.IL-15.CAR-iNKT [invariant NK T (iNKT) cells expressing human CD19 (hCD19) CAR and IL-15]	Recruiting	April 2024
NCT03774654	Phase 1	48	Relapsed or refractory non-Hodgkin lymphoma, chronic lymphocytic leukemia (CLL), acute lymphocytic leukemia (ALL) and small lymphocytic lymphoma	CD19.CAR-allogeneic NK T (aNKT) cells (expresses CD19 antibody, CD28 and IL-15)	Recruiting	March 2035
NCT05487651	Phase 1	36	B-cell malignancies	CD19.CAR-aNKT cells (expresses CD19 CAR and IL-15)	Recruiting	December 2024
NCT05020678	Phase 1	150	B-cell malignancies	NKX019 (CAR NK expressing CD19 and membrane-bound IL-15)	Recruiting	December 2038
NCT04623944	Phase 1	90	AML and myelodysplastic syndromes (MDS)	NKX019	Recruiting	July 2039
NCT05359211	Phase 1	24	Large B-cell lymphoma (including diffuse large B-cell lymphoma, mediastinal large B-cell lymphoma and follicular lymphoma)	Anti-CD19 CAR T cells plus NKTR-255 plus fludarabine plus cyclophosphamide	Recruiting	December 2024
NCT05092451	Phase 1/2	94	B-cell lymphoma. MDS and AML	CAR.70/IL-15-transduced CB-NK cells plus fludarabine plus cyclophosphamide	Recruiting	August 2026
NCT02752243	Phase 1/2	32	MDS and acute leukaemia	IL-15-activated cytokine-induced killer (CIK) cells	Active	March 2024
NCT05618925	Phase 1	20	Non-Hodgkin lymphoma	CD19 t-haNK suspension plus N803 plus various chemotherapy agents	Not yet recruiting	September 2026
NCT06066359	Phase 1/2	44	Multiple myeloma	NY-ESO-1 TCR/IL-15 NK cells plus fludarabine plus cyclophosphamide	Not yet recruiting	August 2028
NCT05667155	Phase 1	48	B-cell non-Hodgkin lymphoma	CB dual CAR-NK19/70 (expresses anti-CD19/CD70 CAR and IL-15)	Recruiting	December 2025
NCT05182073	Phase 1	168	Multiple myeloma	FT576 [expresses B-cell maturation antigen (BCMA) CAR, high-affinity and non-cleavable CD16 (hnCD16) and IL-15/IL-15R fusion protein]	Recruiting	February 2040
NCT03774654	Phase 1	48	Relapsed or refractory non-Hodgkin lymphoma, CLL, ALL and small lymphocytic lymphoma	CD19.CAR-aNKT cells (expresses CD19 antibody, CD28 and IL-15)	Recruiting	March 2035

Declarations

Author contributions

JMV: Formal analysis, Investigation, Validation, Writing—original draft. HFA: Formal analysis, Investigation, Methodology, Writing—original draft. RR: Investigation, Methodology, Validation, Visualization. MB and NC: Investigation, Visualization, Writing—review & editing. EJ: Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing—original draft, Writing—review & editing.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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