Table Info

Table 1.

Summary of studies concerning oligometastatic EGFR mutated NSCLV

Reference	Study	Period	Enrolled patients	Treatments	N metastases; sites	Results (months)	Toxicity > 2
Magnuson et al. [72], 2017	Retrospective	2008–2014	351	TKI +/– SRS or WBRT	1–10; brain	mOS 25, 46, 30	None
Gomez et al. [22], 2019	Randomized, phase II	2012–2016	49	TKI +/–consolidative RT	1–3; NS included brain	mPFS 14.2 vs. 4.4, OS 42.1 vs. 17.0	No grade > 3
Hu et al. [65], 2019	Retrospective	2010–2016	231	TKI +/– LCT	1–5; lung, bone, brain, others	mPFS 15.0 vs. 10.0, mOS 34.0 vs. 21.0	Not reported
Zeng et al. [66], 2020	Retrospective	2015–2019	108	Osimertinib +/– LCT	1–5; lung, bone, adrenal gland, brain, lymph nodes	mPFS 12.8 vs. NR mOS 85.8 vs. 77.1	Not reported
Khan et al. [69], 2022	Randomized		143	Osimertinib +/– LCT	1–3; NS	*	Not reported
Wang et al. [68], 2023	Randomized, phase III	2016–2019	133	1st generation TKI +/– RT	1–5; excluded brain	mPFS 20.2 vs. 12.5 mOS 25.5 vs. 17.4	6% G3–G4 pneumonitis (TKI + RT arm)

SRS: stereotactic radiosurgery; mOS: median OS; mPFS: median PFS; NS: not specified; +/–: with or without. ^* Trial on going

Declarations

Author contributions

FDP and FP: Data curation, Methodology, Writing—original draft. A Bruni and MT: Conceptualization, Supervision, Validation, Writing—review & editing, Validation. A Benini: Writing—review & editing. FL: Writing—review & editing, Validation. All authors read and approved the submitted version.

Conflicts of interest

MT received speakers’ and consultants’ fee from Astra-Zeneca, Pfizer, Eli-Lilly, BMS, Novartis, Roche, MSD, Boehringer Ingelheim, Otsuka, Takeda, Pierre Fabre, Amgen, Merck, Sanofi. MT received institutional research grants from Astra-Zeneca, Boehringer Ingelheim. A Bruni reported travel grants from AstraZeneca, MSD, Ipsen. Other authors have nothing to disclose.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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