Cox proportional hazards regression analysis for factors affecting OS and PFS
| Variable | PFS (univariate analysis) | PFS (multivariate analysis) | OS (univariate analysis) | OS (multivariate analysis) | |||||
|---|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | ||
| Age* | 0.97 (0.94–1.00) | 0.100 | 0.99 (0.95–1.02) | 0.492 | |||||
| RSB score | ≤ 9 | 1 | 1 | ||||||
| > 9 | 1.06 (1.01–1.12) | 0.020 | 1.09 (1.04–1.15) | 0.001 | |||||
| RSB score* | 2.39 (1.31–4.35) | 0.004 | 3.28 (1.71–6.32) | < 0.001 | |||||
| TSB score | ≤ 16 | 1 | 1 | ||||||
| > 16 | 1.03 (1.01–1.07) | 0.011 | 2.29 (1.13–4.66) | 0.022 | 1.05 (1.02–1.08) | 0.001 | 3.64 (1.72–7.71) | 0.001 | |
| TSB score* | 2.99 (1.57–5.67) | 0.001 | 4.17 (2.13–8.17) | < 0.001 | |||||
| ECOG PS | 0–1 | 1 | 1 | ||||||
| 2–4 | 2.57 (1.39–4.77) | 0.003 | 1.68 (0.85–3.31) | 0.137 | 2.97 (1.56–5.66) | 0.001 | 1.59 (0.79–3.22) | 0.194 | |
| KPS | 90–100 | 1 | 1 | ||||||
| ≤ 80 | 3.99 (1.87–8.54) | < 0.001 | 4.28 (1.99–9.23) | < 0.001 | |||||
| cfDNA detectability | No | 1 | 1 | ||||||
| Yes | 2.40 (1.22–4.70) | 0.011 | 2.17 (1.10–4.26) | 0.025 | 1.73 (0.84–3.52) | 0.134 | 1.78 (0.85–3.72) | 0.123 | |
| Weight loss | No | 1 | 1 | ||||||
| Yes | 0.50 (0.22–1.13) | 0.097 | 0.46 (0.19–1.10) | 0.081 | |||||
| Smoking index | ≤ 300 | 1 | 1 | ||||||
| > 300 | 1.21 (0.63–2.33) | 0.572 | 1.46 (0.72–2.97) | 0.297 | |||||
| Fatigue | No | 1 | 1 | ||||||
| Yes | 1.57 (0.82–3.02) | 0.177 | 1.73 (0.86–3.47) | 0.123 | |||||
| TNM 8 stage | III | 1 | 1 | ||||||
| IV | 1.50 (0.82–2.74) | 0.184 | 1.48 (0.78–2.80) | 0.225 | |||||
* Taken as continuous variable. HR: hazards ratio; CI: confidence interval; RSB: respiratory symptom burden; TSB: total symptom burden; OS: overall survival; KPS: Karnofsky performance scale; PFS: progression-free survival; ECOG: Eastern Co-operative Oncology Group; PS: performance status; cfDNA: cell free DNA
