Clinical studies using test systems based on primary tumor cells (the information was obtained using the website ClinicalTrials.gov)
Clinical trial identifier
Estimated enrollment
Cancer type
Cell culture type
Purpose
NCT04298489
40
Gastrointestinal
Primary cell
Explore the clinical feasibility of using the primary cell culture system to guide gastrointestinal cancer chemotherapy (5-fluorouracil, oxaliplatin, irinotecan).
NCT04797676
20
Pancreatic ductal adenocarcinoma
Primary cell
Investigate the difference in the success rate of culturing primary cells obtained by endoscopic ultrasound-guided fine-needle biopsy wet suction technique and surgery.
NCT04342286
20
Kidney cancer
Primary cell (organoid culture)
To establish a sustainable human kidney tumor 3D Matrigel culture system with a stable phenotype.
NCT05813509
30
Ovarian cancer
Primary cell (organoid culture)
Use organoids cultured from patients’ own ovarian cancer tissues as models, and screen potential clinical therapeutic drugs (paclitaxel, carboplatin, lobaplatin, doxorubicin, etc.).
NCT02646228
500
Metastatic cancer
Primary cell
Establishment of patient-derived cancer cell models to interrogate novel molecular targets in metastatic cancer.
The authors declare that they have no conflicts of interest.
Ethical approval
Not applicable.
Consent to participate
Not applicable.
Consent to publication
Not applicable.
Availability of data and materials
Not applicable.
Funding
This paper has been supported by the Russian Science Foundation grant [21-74-10021]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
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